Amlodipine maleate
Based on 15 publication(s) in Google Scholar
Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 88150-47-4
- Formula: C24H29ClN2O9
- Molecular Weight:524.95
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Amlodipine maleate
More- Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
- J Adv Res. 2024 Aug:62:187-198. [Abstract]
- Sci Adv. 2025 Jan 24;11(4):eadp4765. [Abstract]
- Cell Rep. 2026 May 28;45(6):117471. [Abstract]
- Br J Pharmacol. 2022 May;179(9):2054-2077. [Abstract]
- Cells. 2022 Oct 8;11(19):3156. [Abstract]
- Acta Physiol. 2026 Apr;242(4):e70189. [Abstract]
- J Biochem Mol Toxicol. 2022 Oct 7;e23238. [Abstract]
- Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
- J Chem Thermodyn. 2021, 106495.
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Nat Prod Commun. 2024 Mar 20.
- Dissolut Technol. 2021 Jun.
- SSRN. 2025 Nov 6.
- medRxiv. 2025 May 21.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Histological Imaging/Staining
All Calcium Channel Isoforms
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Biological Activity
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L-type calcium channel |
Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3].
Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3].
Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ATP2B1loxP/loxP mice[4]
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Dosage:5 mg/kg/day
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Administration:Subcutaneously implanted osmotic pump for 2 weeks
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Result:Significantly decreased the blood pressure.
Chemical Information
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CAS No. 88150-47-4
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Appearance Solid
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Molecular Weight 524.95
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Formula C24H29ClN2O9
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Color Light yellow to yellow
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SMILES
O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.OC(/C=C\C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (15)
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Journal Impact Factor
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Most Recent
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Exp Mol Med
Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis. [Abstract]2021 Apr;53(4):572-590. PMID: 33811247
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.
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J Adv Res
Calcium Influx: An Essential Process by which α-Synuclein Regulates Morphology of Erythrocytes. [Abstract]2024 Aug:62:187-198. PMID: 37714326 -
Sci Adv
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function. [Abstract]2025 Jan 24;11(4):eadp4765. PMID: 39841844 -
Cell Rep
2026 May 28;45(6):117471. PMID: 42213774 -
Br J Pharmacol
Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. [Abstract]2022 May;179(9):2054-2077. PMID: 34862599 -
Cells
Calcium-Related Genes Predicting Outcomes and Serving as Therapeutic Targets in Endometrial Cancer. [Abstract]2022 Oct 8;11(19):3156. PMID: 36231119 -
Acta Physiol
Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [Abstract]2026 Apr;242(4):e70189. PMID: 41814130 -
J Biochem Mol Toxicol
An in vivo and in vitro model on the protective effect of cilnidipine on contrast-induced nephropathy via regulation of apoptosis and CaMKⅡ/mPTP pathway. [Abstract]2022 Oct 7;e23238. PMID: 36207783 -
Food Chem Toxicol
Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress. [Abstract]2025 Apr:198:115317. PMID: 39938609
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.
Amlodipine maleate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).
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Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
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Solvent & Solubility
DMSO : 120 mg/mL (228.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.71 mg/mL (3.26 mM); Clear solution
This protocol yields a clear solution of ≥ 1.71 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.1 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.71 mg/mL (3.26 mM); Clear solution
This protocol yields a clear solution of ≥ 1.71 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.1 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]
[2]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]
[3]. Kishen G. Bulsara, et al. Amlodipine.
[4]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9049 mL | 9.5247 mL | 19.0494 mL | 47.6236 mL |
| 5 mM | 0.3810 mL | 1.9049 mL | 3.8099 mL | 9.5247 mL | |
| 10 mM | 0.1905 mL | 0.9525 mL | 1.9049 mL | 4.7624 mL | |
| 15 mM | 0.1270 mL | 0.6350 mL | 1.2700 mL | 3.1749 mL | |
| 20 mM | 0.0952 mL | 0.4762 mL | 0.9525 mL | 2.3812 mL | |
| 25 mM | 0.0762 mL | 0.3810 mL | 0.7620 mL | 1.9049 mL | |
| 30 mM | 0.0635 mL | 0.3175 mL | 0.6350 mL | 1.5875 mL | |
| 40 mM | 0.0476 mL | 0.2381 mL | 0.4762 mL | 1.1906 mL | |
| 50 mM | 0.0381 mL | 0.1905 mL | 0.3810 mL | 0.9525 mL | |
| 60 mM | 0.0317 mL | 0.1587 mL | 0.3175 mL | 0.7937 mL | |
| 80 mM | 0.0238 mL | 0.1191 mL | 0.2381 mL | 0.5953 mL | |
| 100 mM | 0.0190 mL | 0.0952 mL | 0.1905 mL | 0.4762 mL |
Amlodipine maleate Related Classifications
HY-B0317A Related Classifications
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