Amlodipine orotate
Based on 14 publication(s) in Google Scholar
Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer.
For research use only. We do not sell to patients.
- CAS No.: 914941-70-1
- Formula: C25H29ClN4O9
- Molecular Weight:564.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Amlodipine orotate
More- J Adv Res. 2024 Aug:62:187-198. [Abstract]
- Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
- Sci Adv. 2025 Jan 24;11(4):eadp4765. [Abstract]
- Br J Pharmacol. 2022 May;179(9):2054-2077. [Abstract]
- Acta Physiol. 2026 Apr;242(4):e70189. [Abstract]
- Cells. 2022 Oct 8;11(19):3156. [Abstract]
- Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
- J Biochem Mol Toxicol. 2022 Oct 7;e23238. [Abstract]
- J Chem Thermodyn. 2021, 106495.
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Nat Prod Commun. 2024 Mar 20.
- Dissolut Technol. 2021 Jun.
- SSRN. 2025 Nov 6.
- medRxiv. 2025 May 21.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Histological Imaging/Staining
All Calcium Channel Isoforms
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Biological Activity
Amlodipine (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3].
Amlodipine (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3].
Amlodipine (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amlodipine (10 mg/kg; i.p. once daily for 20 days) orotate causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ATP2B1loxP/loxP mice[4]
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Dosage:5 mg/kg/day
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Administration:Subcutaneously implanted osmotic pump for 2 weeks
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Result:Significantly decreased the blood pressure.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 914941-70-1
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Molecular Weight 564.97
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Formula C25H29ClN4O9
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SMILES
O=C(C1=CC(NC(N1)=O)=O)O.O=C(C2=C(C)NC(COCCN)=C(C2C3=C(Cl)C=CC=C3)C(OCC)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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J Adv Res
Calcium Influx: An Essential Process by which α-Synuclein Regulates Morphology of Erythrocytes. [Abstract]2024 Aug:62:187-198. PMID: 37714326 -
Exp Mol Med
Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis. [Abstract]2021 Apr;53(4):572-590. PMID: 33811247
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.
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Sci Adv
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function. [Abstract]2025 Jan 24;11(4):eadp4765. PMID: 39841844 -
Br J Pharmacol
Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. [Abstract]2022 May;179(9):2054-2077. PMID: 34862599 -
Acta Physiol
Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [Abstract]2026 Apr;242(4):e70189. PMID: 41814130 -
Cells
Calcium-Related Genes Predicting Outcomes and Serving as Therapeutic Targets in Endometrial Cancer. [Abstract]2022 Oct 8;11(19):3156. PMID: 36231119 -
Food Chem Toxicol
Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress. [Abstract]2025 Feb 10:115317. PMID: 39938609
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.
Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]
H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).
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J Biochem Mol Toxicol
An in vivo and in vitro model on the protective effect of cilnidipine on contrast-induced nephropathy via regulation of apoptosis and CaMKⅡ/mPTP pathway. [Abstract]2022 Oct 7;e23238. PMID: 36207783 -
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Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
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Purity & Documentation
References
[1]. Kishen G. Bulsara, et al. Amlodipine.
[2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]
[3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]
[4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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