2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Amlodipine orotate

Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer.

For research use only. We do not sell to patients.

CAS No. : 914941-70-1

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    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.

    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.

    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.

    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.

    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).

    Amlodipine orotate purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590.  [Abstract]

    Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.

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    Description

    Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer[1][2][3][4].

    In Vitro

    Amlodipine (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3].
    Amlodipine (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3].
    Amlodipine (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Amlodipine orotate Related Antibodies
    In Vivo

    Amlodipine (5 mg/kg/day; s.c. for 2 weeks) orotate significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
    Amlodipine (10 mg/kg; i.p. once daily for 20 days) orotate causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ATP2B1loxP/loxP mice[4]
    Dosage: 5 mg/kg/day
    Administration: Subcutaneously implanted osmotic pump for 2 weeks
    Result: Significantly decreased the blood pressure.
    Clinical Trial
    Molecular Weight

    564.97

    Formula

    C25H29ClN4O9
    CAS No.
    SMILES

    O=C(C1=CC(NC(N1)=O)=O)O.O=C(C2=C(C)NC(COCCN)=C(C2C3=C(Cl)C=CC=C3)C(OCC)=O)OC
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    Amlodipine orotate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Amlodipine914941-70-1Calcium ChannelCa2+ channelsCa channelsoraldihydropyridineantianginalhypertensionInhibitorinhibitorinhibit

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