Amlodipine hydrochloride

Cat. No.: HY-B0317F: Data Sheet Handling Instructions
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Amlodipine hydrochloride is a biologically active drug used to lower blood pressure and prevent chest pain. Amlodipine hydrochloride has shown synergistic effects with antimicrobial drugs in in vitro studies, especially against carbene peptide-resistant Acinetobacter baumannii. Amlodipine hydrochloride can be used in combination with other antibiotics to enhance the inhibitory effect against resistant bacteria. The use of amlodipine hydrochloride helps reduce the dosage requirements of the drug, reduce toxic effects, and delay the emergence of drug resistance.

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CAS No. : 246852-07-3

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Other In-stock Forms of Amlodipine hydrochloride:

Amlodipine Amlodipine maleate Amlodipine besylate

Other Forms of Amlodipine hydrochloride:

(R)-Amlodipine In-stock
Amlodipine In-stock
Amlodipine maleate In-stock
Amlodipine besylate In-stock
Amlodipine mesylate Get quote
Amlodipine orotate Get quote

14 Publications Citing Use of MCE Amlodipine hydrochloride

Cell Imaging/Staining

Cell Proliferation/Viability Assay

Flow Cytometry

In Vivo Efficacy Study

Histological Imaging/Staining

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]; A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC₅₀) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]; Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]; EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]; Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]; H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).

: Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]; Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.

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Purity & Documentation
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Description	Amlodipine hydrochloride is a biologically active drug used to lower blood pressure and prevent chest pain. Amlodipine hydrochloride has shown synergistic effects with antimicrobial drugs in in vitro studies, especially against carbene peptide-resistant Acinetobacter baumannii. Amlodipine hydrochloride can be used in combination with other antibiotics to enhance the inhibitory effect against resistant bacteria. The use of amlodipine hydrochloride helps reduce the dosage requirements of the drug, reduce toxic effects, and delay the emergence of drug resistance^[1].
Molecular Weight	445.34
Formula	C₂₀H₂₆Cl₂N₂O₅
CAS No.	246852-07-3
SMILES	O=C(OCC)C1=C(NC(C)=C(C1C2=CC=CC=C2Cl)C(OC)=O)COCCN.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Kishen G. Bulsara, et al. Amlodipine. [2]. In vitro interactions of ambroxol hydrochloride or amlodipine in combination with antibacterial agents against carbapenem-resistant Acinetobacter baumannii [Content Brief] [3]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief] [4]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief] [5]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]