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Amlodipine hydrochloride

14 Cited Publications
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Based on 14 publication(s) in Google Scholar

Amlodipine hydrochloride is a biologically active drug used to lower blood pressure and prevent chest pain. Amlodipine hydrochloride has shown synergistic effects with antimicrobial drugs in in vitro studies, especially against carbene peptide-resistant Acinetobacter baumannii. Amlodipine hydrochloride can be used in combination with other antibiotics to enhance the inhibitory effect against resistant bacteria. The use of amlodipine hydrochloride helps reduce the dosage requirements of the drug, reduce toxic effects, and delay the emergence of drug resistance.

For research use only. We do not sell to patients.

  • CAS No.: 246852-07-3
  • Formula: C20H26Cl2N2O5
  • Molecular Weight:445.34
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Amlodipine hydrochloride Chemical Structure
    Amlodipine hydrochloride Chemical Structure
  • Experimental Validation Results for Amlodipine hydrochloride
  • Experimental Validation Results for Amlodipine hydrochloride
  • Experimental Validation Results for Amlodipine hydrochloride
  • Experimental Validation Results for Amlodipine hydrochloride
  • Experimental Validation Results for Amlodipine hydrochloride
  • Experimental Validation Results for Amlodipine hydrochloride
CAS No.: 246852-07-3
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  • Amlodipine hydrochloride Chemical Structure
    Amlodipine hydrochloride Chemical Structure
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    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]

    Customer Validation
     A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.

  • 1/16

    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]

    Customer Validation
     Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.

  • 1/16

    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]

    Customer Validation
     EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.

  • 1/16

    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]

    Customer Validation
     Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.

  • 1/16

    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317. [Abstract]

    Customer Validation
     H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).

  • 1/16

    Amlodipine hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]

    Customer Validation
     Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.

  • Amlodipine hydrochloride