914941-70-1
914941-70-1
Chemical Structure
Amlodipine orotate
- CAS No.: 914941-70-1
- Formula:C25H29ClN4O9
- Molecular Weight:564.97
InChIKey: DBGOBQCYSPDGNR-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC(N1)=O)=O)O.O=C(C2=C(C)NC(COCCN)=C(C2C3=C(Cl)C=CC=C3)C(OCC)=O)OC
Biological Activity: Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer[1][2][3][4].
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Amlodipine orotate | Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer. | |||||||||||||||||||||
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References
- [1]. Kishen G. Bulsara, et al. Amlodipine.
- [2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]
- [3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]
- [4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]
Keywords
