Amlodipine-1,1,2,2-d4 maleate
Based on 1 Customer Validation
Amlodipine-1,1,2,2-d4 (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.
For research use only. We do not sell to patients.
- Purity : 98.04%
- CAS No.: 1185246-15-4
- Formula: C24H25D4ClN2O9
- Molecular Weight:528.97
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185246-15-4
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Unlabeled CAS 88150-47-4
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Appearance Solid
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Molecular Weight 528.97
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Formula C24H25D4ClN2O9
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Color Light brown to brown
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SMILES
O=C(O)/C=C\C(O)=O.O=C(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (189.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (949 KB)
- English - EN (949 KB)
- Français - FR (949 KB)
- Deutsch - DE (949 KB)
- Norwegian - NO (949 KB)
- Español - ES (949 KB)
- Swedish - SV (949 KB)
- Italian - IT (949 KB)
- Korean - KR (949 KB)
- Portuguese - PT (949 KB)
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Handling Instructions (2659 KB)
References
[1]. Kishen G. Bulsara, et al. Amlodipine.
[2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]
[3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]
[4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]
[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8905 mL | 9.4523 mL | 18.9047 mL | 47.2617 mL |
| 5 mM | 0.3781 mL | 1.8905 mL | 3.7809 mL | 9.4523 mL | |
| 10 mM | 0.1890 mL | 0.9452 mL | 1.8905 mL | 4.7262 mL | |
| 15 mM | 0.1260 mL | 0.6302 mL | 1.2603 mL | 3.1508 mL | |
| 20 mM | 0.0945 mL | 0.4726 mL | 0.9452 mL | 2.3631 mL | |
| 25 mM | 0.0756 mL | 0.3781 mL | 0.7562 mL | 1.8905 mL | |
| 30 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL | 1.5754 mL | |
| 40 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1815 mL | |
| 50 mM | 0.0378 mL | 0.1890 mL | 0.3781 mL | 0.9452 mL | |
| 60 mM | 0.0315 mL | 0.1575 mL | 0.3151 mL | 0.7877 mL | |
| 80 mM | 0.0236 mL | 0.1182 mL | 0.2363 mL | 0.5908 mL | |
| 100 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4726 mL |
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