1. Signaling Pathways
  2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugate
  4. E3 Ligase Ligand-Linker Conjugate Inhibitors

E3 Ligase Ligand-Linker Conjugate Inhibitors

von Hippel-Lindau (VHL)

MDM2

Cereblon

cIAP1

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E3 Ligase Ligand-Linker Conjugate
Product Name von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Purity
Pomalidomide-PEG4-C-COOH    
Cereblon
  >95.0%
Thalidomide-O-amido-C4-N3    
Cereblon
  95.74%
Thalidomide-O-amido-C8-NH2 (TFA)    
Cereblon
  99.20%
Thalidomide-O-amido-PEG3-C2-NH2 (TFA)    
Cereblon
  99.04%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL
      99.02%
Pomalidomide-PEG3-C2-NH2 (TFA)    
Cereblon
  99.00%
Thalidomide-O-amido-C3-NH2 (TFA)    
Cereblon
 
Pomalidomide-PEG3-C2-NH2    
Cereblon
 
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VHL
      96.24%
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
VHL
      98.34%
Thalidomide-O-amido-C3-COOH    
Cereblon
  98.88%
Thalidomide-O-amido-C4-NH2 (TFA)    
Cereblon
  99.74%
Pomalidomide-PEG4-C2-NH2    
Cereblon
  95.11%
(S,R,S)-AHPC-PEG4-N3
VHL
      98.23%
(S,R,S)-AHPC-PEG2-N3
VHL
      97.99%
Pomalidomide-PEG4-Ph-NH2    
Cereblon
  >98.0%
(S,R,S)-AHPC-PEG1-N3
VHL
      98.18%
(S,R,S)-AHPC-PEG3-N3
VHL
      97.19%
Thalidomide-O-amido-PEG2-C2-NH2 (TFA)    
Cereblon
  99.52%
Thalidomide-O-amido-C6-NH2 (TFA)    
Cereblon
  99.42%
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
VHL
      96.30%
Thalidomide-O-amido-PEG1-(C1-​PEG)2-C2-NH2    
Cereblon
  96.77%
(S,R,S)-AHPC-PEG4-NH2
VHL
      98.26%
(S,R,S)-AHPC-C3-NH2
VHL
      95.26%
Thalidomide-O-amido-C4-NH2    
Cereblon
 
(S,R,S)-AHPC-PEG3-NH2
VHL
     
(S,R,S)-AHPC-PEG2-NH2
VHL
     
Thalidomide-O-amido-PEG3-C2-NH2    
Cereblon
 
E3 ligase Ligand-Linker Conjugates 21
VHL
     
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH    
Cereblon
 
Nutlin-C1-amido-PEG4-C2-N3  
MDM2
   
Pomalidomide-PEG1-C2-N3    
Cereblon
 
Pomalidomide-PEG2-Tos    
Cereblon
 
Lenalidomide-acetylene-C5-COOH    
Cereblon
 
(S,R,S)-AHPC-PEG1-OTs
VHL
     
VHL Ligand-Linker Conjugates 15
VHL
     
Pomalidomide-amido-C4-amido-C6-NH-Boc    
Cereblon
 
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc    
Cereblon
 
cIAP1 Ligand-Linker Conjugates 13      
cIAP1
cIAP1 Ligand-Linker Conjugates 15 hydrochloride      
cIAP1
cIAP1 Ligand-Linker Conjugates 14      
cIAP1
AhR Ligand-Linker Conjugates 1      
cIAP1
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride      
cIAP1
cIAP1 Ligand-Linker Conjugates 1      
cIAP1
cIAP1 Ligand-Linker Conjugates 3      
cIAP1
cIAP1 Ligand-Linker Conjugates 10      
cIAP1
VH032-thiol-C6-NH2
VHL
     
(S,R,S)-AHPC-PEG5-COOH
VHL
     
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride      
cIAP1
cIAP1 Ligand-Linker Conjugates 15      
cIAP1
cIAP1 Ligand-Linker Conjugates 9      
cIAP1
cIAP1 Ligand-Linker Conjugates 11      
cIAP1
cIAP1 Ligand-Linker Conjugates 12      
cIAP1
cIAP1 Ligand-Linker Conjugates 8      
cIAP1
cIAP1 Ligand-Linker Conjugates 7      
cIAP1
cIAP1 Ligand-Linker Conjugates 5      
cIAP1
cIAP1 Ligand-Linker Conjugates 4      
cIAP1
cIAP1 Ligand-Linker Conjugates 2      
cIAP1
cIAP1 Ligand-Linker Conjugates 6 hydrochloride      
cIAP1
Thalidomide-O-amido-C8-NH2    
Cereblon