1. Signaling Pathways
  2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugate
  4. E3 Ligase Ligand-Linker Conjugate Inhibitors

E3 Ligase Ligand-Linker Conjugate Inhibitors

von Hippel-Lindau (VHL)

MDM2

Cereblon

cIAP1

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E3 Ligase Ligand-Linker Conjugate
Product Name von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Purity
Thalidomide-O-amido-C4-N3    
Cereblon
  98.63%
Pomalidomide-PEG4-C-COOH    
Cereblon
  ≥95.0%
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
VHL
      99.44%
Pomalidomide-PEG4-C2-NH2    
Cereblon
  95.11%
Thalidomide-O-amido-C8-NH2 TFA    
Cereblon
  99.11%
Pomalidomide-PEG3-azide    
Cereblon
  98.44%
Pomalidomide 4'-alkylC5-acid    
Cereblon
  98.78%
Pomalidomide-PEG2-azide    
Cereblon
  95.01%
(S,R,S)-AHPC-PEG2-N3
VHL
      97.99%
Thalidomide-O-amido-C3-COOH    
Cereblon
  99.49%
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VHL
      96.24%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL
      99.02%
(S,R,S)-AHPC-PEG3-N3
VHL
      95.11%
(S,R,S)-AHPC-PEG4-N3
VHL
      98.83%
Pomalidomide-PEG3-C2-NH2 TFA    
Cereblon
  99.0%
(S,R,S)-AHPC-PEG1-N3
VHL
      98.41%
Lenalidomide-C5-NH2    
Cereblon
  98.94%
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
VHL
      96.30%
Thalidomide-O-amido-PEG3-C2-NH2 TFA    
Cereblon
  99.55%
Thalidomide-O-amido-C3-NH2 TFA    
Cereblon
  98.18%
VH032-PEG3-acetylene
VHL
      96.57%
Lenalidomide-C4-NH2 hydrochloride    
Cereblon
  98.24%
Pomalidomide-C7-COOH    
Cereblon
  98.04%
(S,R,S)-AHPC-C4-NH2 hydrochloride
VHL
      95.35%
Pomalidomide-PEG4-Ph-NH2    
Cereblon
  ≥98.0%
(S,R,S)-AHPC-PEG5-COOH
VHL
      95.01%
Thalidomide-O-amido-C4-NH2 TFA    
Cereblon
  99.74%
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH    
Cereblon
  95.02%
Lenalidomide-propargyl-C2-NH2 hydrochloride    
Cereblon
  99.08%
Pomalidomide-PEG4-azide    
Cereblon
  96.05%
Thalidomide-O-amido-C6-NH2 TFA    
Cereblon
  99.82%
(S,R,S)-AHPC-C8-NH2
VHL
      95.05%
Lenalidomide-C5-NH2 hydrochloride    
Cereblon
  98.45%
Thalidomide-NH-C6-NH-Boc    
Cereblon
  96.11%
Thalidomide-O-amido-PEG2-C2-NH2 TFA    
Cereblon
  99.52%
Pomalidomide-PEG1-C2-N3    
Cereblon
  99.65%
Thalidomide-O-PEG2-propargyl    
Cereblon
  97.57%
Lenalidomide-acetylene-C5-COOH    
Cereblon
  95.48%
Thalidomide-O-amido-PEG1-(C1-​PEG)2-C2-NH2    
Cereblon
  96.77%
Pomalidomide-C2-NH2 hydrochloride    
Cereblon
  96.05%
Pomalidomide-amido-C1-Br    
Cereblon
 
(S,R,S)-AHPC-PEG5-Boc
VHL
      95.29%
Thalidomide-O-amido-C4-NH2    
Cereblon
 
(S,R,S)-AHPC-PEG3-NH2
VHL
     
(S,R,S)-AHPC-C6-NH2 hydrochloride
VHL
     
Thalidomide-NH-C6-NH2 TFA    
Cereblon
  99.82%
(S,R,S)-AHPC-PEG2-NH2
VHL
     
Thalidomide-O-amido-PEG3-C2-NH2    
Cereblon
 
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
VHL
      95.06%
(S,R,S)-AHPC-PEG4-NH2
VHL
      98.26%
Pomalidomide-PEG3-C2-NH2    
Cereblon
 
Pomalidomide 4'-PEG5-acid    
Cereblon
  95.02%
(S,R,S)-AHPC-Me-C10-Br
VHL
     
(S,R,S)-AHPC-C10-NH2
VHL
     
(S,R,S)-AHPC-C10-NH2 dihydrochloride
VHL
     
Thalidomide-NH-C10-COOH
VHL
     
(S,R,S)-AHPC-PEG3-propionic acid
VHL
     
(S,R,S)-AHPC-C4-NH2 dihydrochloride
VHL
     
VH032-PEG1-NH2 dihydrochloride
VHL
     
Thalidomide-O-amido-C4-NH2 hydrochloride    
Cereblon
 
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride    
Cereblon
 
Nutlin-C1-amido-PEG4-C2-N3  
MDM2
   
Thalidomide-NH-PEG3-propionic acid    
Cereblon
 
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride    
Cereblon
 
cIAP1 Ligand-Linker Conjugates 1      
cIAP1
Pomalidomide-PEG4-C2-NH2 hydrochloride    
Cereblon
 
Thalidomide-NH-PEG2-C2-NH-Boc    
Cereblon
  98.17%
Thalidomide-O-amido-C6-NH2 hydrochloride    
Cereblon
 
Thalidomide-PEG2-C2-NH2 TFA    
Cereblon
  98.85%
Thalidomide-O-amido-C3-PEG3-C1-NH2    
Cereblon
 
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride    
Cereblon
 
(S,R,S)-AHPC-O-Ph-PEG1-NH2
VHL
     
Pomalidomide-PEG1-C2-COOH    
Cereblon
 
Thalidomide-O-C6-NH2 TFA    
Cereblon
 
Thalidomide-NH-PEG4-Ms    
Cereblon
 
(S,R,S)-AHPC-C3-NH2
VHL
     
(S,R,S)-AHPC-C4-NH2
VHL
     
Thalidomide-NH-C4-NH-Boc    
Cereblon
 
(S,R,S)-AHPC-Me-C5-COOH
VHL
     
Thalidomide-NH-PEG4-COOH    
Cereblon
 
Pomalidomide-amido-PEG3-C2-NH2    
Cereblon
 
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
VHL
     
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride    
Cereblon
 
VHL Ligand-Linker Conjugates 15
VHL
     
Pomalidomide-amido-C3-COOH    
Cereblon
 
(S,R,S)-AHPC-C2-PEG4-N3
VHL
     
(S,R,S)-AHPC-Me-C10-NH2
VHL
     
Pomalidomide-amido-C4-amido-C6-NH-Boc    
Cereblon
 
Thalidomide-NH-C2-PEG3-OH    
Cereblon
 
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc    
Cereblon
 
cIAP1 Ligand-Linker Conjugates 15 hydrochloride      
cIAP1
(S,R,S)-AHPC-C7-amine
VHL
     
cIAP1 Ligand-Linker Conjugates 14      
cIAP1
A 410099.1 amide-PEG3-amine-Boc      
cIAP1
AhR Ligand-Linker Conjugates 1      
cIAP1
(S,R,S)-AHPC-C5-NH2
VHL
     
Thalidomide-C2-amido-C2-COOH    
Cereblon
 
cIAP1 Ligand-Linker Conjugates 3      
cIAP1
VH032-thiol-C6-NH2
VHL
     
A 410099.1 amide-PEG2-amine-Boc      
cIAP1
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride      
cIAP1
cIAP1 Ligand-Linker Conjugates 15      
cIAP1
cIAP1 Ligand-Linker Conjugates 11      
cIAP1
A 410099.1, amine-Boc hydrochloride      
cIAP1
cIAP1 Ligand-Linker Conjugates 12      
cIAP1
Boc-A 410099.1 amide-alkylC4-amine      
cIAP1
cIAP1 Ligand-Linker Conjugates 5      
cIAP1
cIAP1 Ligand-Linker Conjugates 2      
cIAP1
Thalidomide-NH-PEG8-Ts    
Cereblon
 
Thalidomide-O-amido-C8-NH2    
Cereblon