2. シグナル伝達
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. von Hippel-Lindau (VHL) Isoform

von Hippel-Lindau (VHL)

 

von Hippel-Lindau (VHL) 関連製品 (72):

製品番号 製品名 CAS 番号 純度 構造式
  • HY-W998310
    (S,R,S)-AHPC-Me-CO-C4-COOH 2349429-73-6 99.75%
    (S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12 (HY-174453). PROTAC ERα Degrader-12 is a potent and highly selective ERα PROTAC degrader.
    (S,R,S)-AHPC-Me-CO-C4-COOH
  • HY-129941
    (S,R,S)-AHPC-C10-NH2 2341796-74-3
    (S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.
    (S,R,S)-AHPC-C10-NH2
  • HY-136006
    (S,R,S)-AHPC-C6-NH2 dihydrochloride 2341796-77-6
    (S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 dihydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.
    (S,R,S)-AHPC-C6-NH2 dihydrochloride
  • HY-133487
    (S,R,S)-AHPC-C8-NH2 dihydrochloride 2341796-80-1
    (S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.
    (S,R,S)-AHPC-C8-NH2 dihydrochloride
  • HY-130711A
    (S,R,S)-AHPC-C3-NH2 TFA 2688842-02-4
    (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.
    (S,R,S)-AHPC-C3-NH2 TFA
  • HY-136008A
    (S,R,S)-AHPC-PEG1-NH2 dihydrochloride 2341796-83-4
    (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-PEG1-NH2 dihydrochloride can be used to design PROTACs.
    (S,R,S)-AHPC-PEG1-NH2 dihydrochloride
  • HY-130711
    (S,R,S)-AHPC-C3-NH2 2361119-88-0
    (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.
    (S,R,S)-AHPC-C3-NH2
  • HY-125846
    (S,R,S)-AHPC-PEG1-OTs
    (S,R,S)-AHPC-PEG1-OTs is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.
    (S,R,S)-AHPC-PEG1-OTs
  • HY-114176A
    (S,R,S)-AHPC-C4-NH2 2138439-53-7
    (S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.
    (S,R,S)-AHPC-C4-NH2
  • HY-125906
    VHL Ligand-Linker Conjugates 15 2375564-62-6
    VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs.
    VHL Ligand-Linker Conjugates 15
  • HY-130847
    (S,R,S)-AHPC-Me-C10-NH2 2376139-52-3
    (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).
    (S,R,S)-AHPC-Me-C10-NH2
  • HY-179435
    (S,R,S)-AHPC-Bromooctanoic acid 2408342-03-8
    (S,R,S)-AHPC-Bromooctanoic acid is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding linker (HY-W007700). (S,R,S)-AHPC-Bromooctanoic acid can serve as VHL (von Hippel-Lindau) ligand to recruit the VHL protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-Bromooctanoic acid
  • HY-136186
    (S,R,S)-AHPC-C7-amine 2306389-04-6
    (S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader.
    (S,R,S)-AHPC-C7-amine
  • HY-176366
    AHPC-PEG6-CH2COOH 2361117-11-3
    AHPC-PEG6-CH2COOH is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand and 6-unit PEG linker (HY-122702). AHPC-PEG6-CH2COOH can be used for synthesis of PROTAC CMP98 (HY-136257).
    AHPC-PEG6-CH2COOH
  • HY-133046
    VHL Ligand-Linker Conjugates 17
    VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader. VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VHL Ligand-Linker Conjugates 17
  • HY-174875
    (S,R,S)-AHPC-CO-C2-phenylboronic acid
    (S,R,S)-AHPC-CO-C2-phenylboronic acid is an E3 ligase ligand-linker conjugate that incorporates the VH032-based VHL ligand (HY-125845) and linker. (S,R,S)-AHPC-CO-C2-phenylboronic acid can be used for synthesis of PROTAC AF151 (HY-174873).
    (S,R,S)-AHPC-CO-C2-phenylboronic acid
  • HY-136187
    (S,R,S)-AHPC-C5-NH2 2170695-19-7
    (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader.
    (S,R,S)-AHPC-C5-NH2
  • HY-174474
    (S,R,S)-AHPC-Me-amide-C15-acid
    (S,R,S)-AHPC-Me-amide-C15-acid is a synthesized E3 ligase ligand-linker conjugate that can be used for synthesis of PROTACs such as C199 (HY-174445).
    (S,R,S)-AHPC-Me-amide-C15-acid
  • HY-181734
    E3 Ligase Ligand-linker Conjugate 224
    E3 Ligase Ligand-linker Conjugate 224 is an E3 Ligase Ligand-Linker Conjugate that incorporates a ligand for VHL (HY-170348) and a PROTAC linker (HY-W895436). E3 Ligase Ligand-linker Conjugate 224 can be used for synthesis of KRAS G12D PROTAC degrader MS243 (HY-181728).
    E3 Ligase Ligand-linker Conjugate 224
  • HY-111824
    VH032-thiol-C6-NH2 2098836-63-4
    VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
    VH032-thiol-C6-NH2