2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W709961
    5-OAHSA
    		99.9%
    5-OAHSA (1-(3-Carboxypropyl)tetradecyl (9Z)-9-octadecenoate) is a endogenous lipid. 5-OAHSA reduces the level of blood glucose, improves the glucose tolerance, and stimulates the the secretion of GLP-1 and insulin. 5-OAHSA exhibits potential in regulating metabolic and inflammatory responses.
    5-OAHSA
  • HY-W012382R
    N-Acetyl-L-tyrosine (Standard)
    N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer.
    N-Acetyl-L-tyrosine (Standard)
  • HY-W016750R
    Pentane-1,5-diamine dihydrochloride (Standard)
    Pentane-1,5-diamine dihydrochloride is an endogenous metabolite.
    Pentane-1,5-diamine dihydrochloride (Standard)
  • HY-W012974R
    3-Aminoisobutyric acid (Standard)
    3-Aminoisobutyric acid (Standard) is the analytical standard of 3-Aminoisobutyric acid. This product is used for research and analytical applications. 3-Aminoisobutyric acid (β-Aminoisobutyric acid) exhibits anti-inflammatory and antioxidant effects. It increases the expression of brown fat cell-specific genes in white adipose tissue and enhances fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid alleviates insulin resistance and inflammation induced by palmitic acid or a high-fat diet in mice via the AMPK–PPARδ-dependent pathway. 3-Aminoisobutyric acid is a catabolite of thymine and valine in skeletal muscle.
    3-Aminoisobutyric acid (Standard)
  • HY-157829
    (R)-Palmitoyl-(2-methyl)ethanolamide
    		99.0%
    (R)-Palmitoyl-(2-methyl)ethanolamide (Me-PEA) is a competitive inhibitor of [3 H]-AEA metabolism with a Ki value of 6.6 μM.
    (R)-Palmitoyl-(2-methyl)ethanolamide
  • HY-W009283
    2-(2-(Diphenylphosphino)ethyl)pyridine
    2-(2-(Diphenylphosphino)ethyl)pyridine is an important chiral catalyst with excellent catalytic activity. 2-(2-(Diphenylphosphino)ethyl)pyridine is widely used in asymmetric synthesis reactions, especially in the field of compound synthesis. 2-(2-(Diphenylphosphino)ethyl)pyridine can also be used in metal-catalyzed reactions to improve the selectivity and yield of the reaction.
    2-(2-(Diphenylphosphino)ethyl)pyridine
  • HY-B1189S
    Meglutol-d3
    		98.04%
    Meglutol-d3 is the deuterium labeled Meglutol. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
    Meglutol-d<sub>3</sub>
  • HY-W251779
    3-Sulfopropanoic acid
    3-Sulfopropanoic acid (3-Sulfopropionic acid) is a Endogenous metabolite product.
    3-Sulfopropanoic acid
  • HY-N1446A
    Glycerol Monoleate
    Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery.
    Glycerol Monoleate
  • HY-113093S
    Ethyl glucuronide-d5
    Ethyl glucuronide-d5 is the deuterium labeled Ethyl glucuronide (HY-113093). Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.
    Ethyl glucuronide-d<sub>5</sub>
  • HY-100045
    p-Nitrophenyl phosphorylcholine
    		99.82%
    p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
    p-Nitrophenyl phosphorylcholine
  • HY-136648AR
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard)
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard) (dATP trisodium (Standard)) is the analytical standard of 2'-Deoxyadenosine-5'-triphosphate trisodium (HY-136648A). This product is intended for research and analytical applications. 2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard)
  • HY-107494R
    13-cis-4-Oxoretinoic acid (Standard)
    13-cis-4-Oxoretinoic acid (Standard) is the analytical standard of 13-cis-4-Oxoretinoic acid (HY-107494). This product is intended for research and analytical applications. 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .
    13-cis-4-Oxoretinoic acid (Standard)
  • HY-Y0181R
    D-Pipecolinic acid (Standard)
    D-Pipecolinic acid is a normal human metabolite found in human biofluids.
    D-Pipecolinic acid (Standard)
  • HY-128699R
    D-Desthiobiotin (Standard)
    D-Desthiobiotin (Standard) is the analytical standard of D-Desthiobiotin. This product is intended for research and analytical applications. D-Desthiobiotin is a biotin derivative. D-Desthiobiotin increases testosterone. D-Desthiobiotin is used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation.
    D-Desthiobiotin (Standard)
  • HY-W017389S1
    Xanthine-15N2
    		99.35%
    Xanthine-15N2 is a 15N-labeled Xanthine (HY-W017389). Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation.
    Xanthine-<sup>15</sup>N<sub>2</sub>
  • HY-113208
    13,14-Dihydro-15-keto Prostaglandin F2α
    		99.0%
    13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy.
    13,14-Dihydro-15-keto Prostaglandin F2α
  • HY-N0729S5
    Linoleic acid-d2
    		98.52%
    Linoleic Acid-d2 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism.
    Linoleic acid-d<sub>2</sub>
  • HY-113081S
    1-Methyladenosine-d3
    1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis.
    1-Methyladenosine-d<sub>3</sub>
  • HY-W165608
    5-(3'-Hydroxyphenyl)-γ-valerolactone
    		99.90%
    5-(3'-Hydroxyphenyl)-γ-valerolactone is a flavan-3-ols metabolitec of human faecal microbiota.
    5-(3'-Hydroxyphenyl)-γ-valerolactone
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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