Endogenous Metabolite

Related Products

Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health^[1]^[2]^[3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets^[1]^[2]^[3].

References:

[1]. Seyedsayamdost MR. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311.

[2]. Ruiz B, et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit Rev Microbiol. 2010 May;36(2):146-67.

[3]. Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019 Oct 1;99(4):1819-1875.

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492)
Antibodies (477)
Endogenous Metabolite Isoform Comparison

By Effects:	Inhibitors (66) Agonists (3) Controls (2) Antagonist (1) Activators (7) Modulators (9) Chemicals (14) Inducers (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-113408

Tiglyl carnitine		99.83%
Tiglyl carnitine is found to be associated with celiac disease and mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

HY-W015224

Methyl 2-(1H-indol-3-yl)acetate		99.90%
Methyl 2-(1H-indol-3-yl)acetate is an indole ester.Methyl 2-(1H-indol-3-yl)acetate serves as a precursor for synthesis of S-alkylated/aralkylated 2-(1H-indol-3-ylmethyl)-1,3,4-oxadiazole-5-thiol derivatives.

HY-76547

p-Toluic acid		99.93%
p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis.

HY-124265

4β-Hydroxycholesterol		99.96%
4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation.

HY-108398B

11(Z),14(Z),17(Z)-Eicosatrienoic acid		99.94%
11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid that can maintain the continued replication of functional mitochondria in Saccharomyces cerevisiae (KD115).

HY-N1902S

4-Hydroxyphenylacetic acid-d₆		99.16%
4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.

HY-W017469

Mesitaldehyde		98.13%
Mesitaldehyde is an endogenous metabolite.

HY-113266

Valerylcarnitine		≥99.0%
Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines. Valerylcarnitine acts as a metabolomic biomarker for ionizing radiation exposure in nonhuman primates. Valerylcarnitine can be used for the research of type 1 diabetes.

HY-B1716S

L-5-Hydroxytryptophan-d₃		99.9%
L-5-Hydroxytryptophan-d₃ is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

HY-125773

β-cyano-L-Alanine		99.90%
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

HY-113411S

3-Hydroxyglutaric acid-d₅		99.72%
3-Hydroxyglutaric acid-d₅ is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative.

HY-18260S

Bisphenol A-d₁₆		99.95%
Bisphenol A-d₁₆ is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.

HY-113327

1,3,7-Trimethyluric acid		99.99%
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort.

HY-Y0252S5

L-Proline-d₇		99.3%
L-Proline-d₇ is the deuterium labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-118774

Propofol β-D-glucuronide		99.55%
Propofol β-D-glucuronide is a metabolite of Propofol sulfate and can be used for diagnosis to distinguish colorectal cancer from healthy individuals.

HY-N0172R

Caffeic acid (Standard)
Caffeic acid (Standard) is the analytical standard of Caffeic acid. This product is intended for research and analytical applications. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).

HY-B1337R

Choline chloride (Standard)
Choline (chloride) (Standard) is the analytical standard of Choline (chloride). This product is intended for research and analytical applications. Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.

HY-A0070R

Liothyronine sodium (Standard)
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-W015851S2

(R)-3-Hydroxybutanoic acid-¹³C₄ sodium		98.0%
(R)-3-Hydroxybutanoic acid-¹³C₄ sodium is a ¹³C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones.

HY-N2024AS1

Maltose-¹³C₁₂ monohydrate		99.50%
Maltose monohydrate-¹³C₁₂ is the ¹³C labeled isotope of Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Related Products (8492)

Antibodies (477)

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492):