β-cyano-L-Alanine
Based on 1 Customer Validation
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 6232-19-5
- Formula: C4H6N2O2
- Molecular Weight:114.10
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult (postnatal age: 60 days) male C57BL/6J mice (25-30 g) gavage-fed with ethanol[2]
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Dosage:50 mg/kg
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Administration:Intraperitoneally
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Result:Abolished the protective effect of ethanol on cerebral I/R injury.
Chemical Information
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CAS No. 6232-19-5
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Appearance Solid
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Molecular Weight 114.10
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Formula C4H6N2O2
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Color White to light yellow
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SMILES
N[C@@H](CC#N)C(O)=O
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Synonyms
Beta-cyano-l-alanine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
H2O : 20 mg/mL (175.28 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (876.42 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Piotrowski M, et al. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.J Med Chem. J Biol Chem. 2001 Jan 26;276(4):2616-21. [Content Brief]
[2]. McCarter KD, et al. Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase. Alcohol. 2019 May;76:81-89. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.7642 mL | 43.8212 mL | 87.6424 mL | 219.1061 mL |
| 5 mM | 1.7528 mL | 8.7642 mL | 17.5285 mL | 43.8212 mL | |
| 10 mM | 0.8764 mL | 4.3821 mL | 8.7642 mL | 21.9106 mL | |
| 15 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
| 20 mM | 0.4382 mL | 2.1911 mL | 4.3821 mL | 10.9553 mL | |
| 25 mM | 0.3506 mL | 1.7528 mL | 3.5057 mL | 8.7642 mL | |
| 30 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 40 mM | 0.2191 mL | 1.0955 mL | 2.1911 mL | 5.4777 mL | |
| 50 mM | 0.1753 mL | 0.8764 mL | 1.7528 mL | 4.3821 mL | |
| 60 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 80 mM | 0.1096 mL | 0.5478 mL | 1.0955 mL | 2.7388 mL | |
| 100 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
β-cyano-L-Alanine Related Classifications
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