3-Hydroxyglutaric acid-d5
Based on 1 Customer Validation
3-Hydroxyglutaric acid-d5 is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 1219805-72-7
- Formula: C5H3D5O5
- Molecular Weight:153.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219805-72-7
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Unlabeled Cas 638-18-6
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Appearance Solid
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Molecular Weight 153.14
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Formula C5H3D5O5
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Color White to off-white
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SMILES
OC(C([2H])([2H])C(O)([2H])C([2H])([2H])C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 250 mg/mL (1632.49 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Rosa RB, et al. Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats. Neurochem Int. 2004 Dec;45(7):1087-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.5300 mL | 32.6499 mL | 65.2997 mL | 163.2493 mL |
| 5 mM | 1.3060 mL | 6.5300 mL | 13.0599 mL | 32.6499 mL | |
| 10 mM | 0.6530 mL | 3.2650 mL | 6.5300 mL | 16.3249 mL | |
| 15 mM | 0.4353 mL | 2.1767 mL | 4.3533 mL | 10.8833 mL | |
| 20 mM | 0.3265 mL | 1.6325 mL | 3.2650 mL | 8.1625 mL | |
| 25 mM | 0.2612 mL | 1.3060 mL | 2.6120 mL | 6.5300 mL | |
| 30 mM | 0.2177 mL | 1.0883 mL | 2.1767 mL | 5.4416 mL | |
| 40 mM | 0.1632 mL | 0.8162 mL | 1.6325 mL | 4.0812 mL | |
| 50 mM | 0.1306 mL | 0.6530 mL | 1.3060 mL | 3.2650 mL | |
| 60 mM | 0.1088 mL | 0.5442 mL | 1.0883 mL | 2.7208 mL | |
| 80 mM | 0.0816 mL | 0.4081 mL | 0.8162 mL | 2.0406 mL | |
| 100 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6325 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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