3-Hydroxyglutaric acid

Name: 3-Hydroxyglutaric acid
Brand: MedChemExpress
SKU: HY-113411
Rating: 4.5 (1 reviews)

Cat. No.: HY-113411 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Hydroxyglutaric acid is a glutaric acid derivative.

For research use only. We do not sell to patients.

3-Hydroxyglutaric acid Chemical Structure

CAS No. : 638-18-6

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 3-Hydroxyglutaric acid:

3-Hydroxyglutaric acid-d₅ In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

3-Hydroxyglutaric acid is a glutaric acid derivative.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

148.11

Formula

C₅H₈O₅

CAS No.

638-18-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(O)CC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1687.93 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7517 mL	33.7587 mL	67.5174 mL
5 mM	1.3503 mL	6.7517 mL	13.5035 mL
10 mM	0.6752 mL	3.3759 mL	6.7517 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (675.17 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) RP-HPLC (150 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Rosa RB, et al. Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats. Neurochem Int. 2004 Dec;45(7):1087-94. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.7517 mL	33.7587 mL	67.5174 mL	168.7935 mL
	5 mM	1.3503 mL	6.7517 mL	13.5035 mL	33.7587 mL
	10 mM	0.6752 mL	3.3759 mL	6.7517 mL	16.8793 mL
	15 mM	0.4501 mL	2.2506 mL	4.5012 mL	11.2529 mL
	20 mM	0.3376 mL	1.6879 mL	3.3759 mL	8.4397 mL
	25 mM	0.2701 mL	1.3503 mL	2.7007 mL	6.7517 mL
	30 mM	0.2251 mL	1.1253 mL	2.2506 mL	5.6264 mL
	40 mM	0.1688 mL	0.8440 mL	1.6879 mL	4.2198 mL
	50 mM	0.1350 mL	0.6752 mL	1.3503 mL	3.3759 mL
	60 mM	0.1125 mL	0.5626 mL	1.1253 mL	2.8132 mL
	80 mM	0.0844 mL	0.4220 mL	0.8440 mL	2.1099 mL
	100 mM	0.0675 mL	0.3376 mL	0.6752 mL	1.6879 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.