2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171681
    Anti-CCL2 (Carlumab)-SPDB-DM4
    		Inhibitor
    Anti-CCL2 (Carlumab)-SPDB-DM4 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker SPDB (HY-12448) and the tubulin inhibitor DM4 (HY-12454). The ADC toxic molecule and linker part are sulfo-SPDB-DM4 (HY-101141). Anti-CCL2 (Carlumab)-SPDB-DM4 can be used in cancer research.
    Anti-CCL2 (Carlumab)-SPDB-DM4
  • HY-183790
    SMU-G4
    		Inhibitor
    SMU-G4 is a Tubulin polymerization inhibitor. SMU-G4 induces G2/M phase cell cycle arrest, triggers Apoptosis, and upregulates the expression of Cleaved-Caspase 3. SMU-G4 exhibits in vivo anti-tumor activity in melanoma xenograft models. SMU-G4 can be used for research related to melanoma.
    SMU-G4
  • HY-179516
    AKT1-IN-11
    		Inhibitor
    AKT1-IN-11, a Podophyllotoxin (HY-15552) derivative, is a AKT1/tubulin dual inhibitor. AKT1-IN-11 down-regulates the phosphorylation level of AKT kinase in tumor cells, disrupting cell proliferation, causeing G2/M phase arrest and inducing apoptosis. AKT1-IN-11 also promotes tubulin depolymerization. AKT1-IN-11 can be used for the research of colorectal cancer.
    AKT1-IN-11
  • HY-179159
    Tubulin-IN-60
    		Inhibitor
    Tubulin-IN-60 (Compound 4) is a tubulin polymerization inhibitor, with an IC50 of 0.19 μM. Tubulin-IN-60 has anti-cancer activity against colorectal, pancreatic, T-cell acute lymphoblastic leukemia cancer.
    Tubulin-IN-60
  • HY-155249
    KGP591
    		Inhibitor
    KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA).
    KGP591
  • HY-169096
    DPP-21
    		Inhibitor
    DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax).
    DPP-21
  • HY-161641
    Tubulin polymerization-IN-62
    		Inhibitor
    Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC50 is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model.
    Tubulin polymerization-IN-62
  • HY-133222
    STX140
    		Inhibitor
    STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities.
    STX140
  • HY-B0011AR
    Docetaxel Trihydrate (Standard)
    		Inhibitor
    Docetaxel (Trihydrate) (Standard) is the analytical standard of Docetaxel (Trihydrate). This product is intended for research and analytical applications. Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC50 value of 0.2 μM. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis.
    Docetaxel Trihydrate (Standard)
  • HY-177413
    Tub114
    		Inhibitor
    Tub114 is a drug-linker conjugate for ADC. Tub114 is a Tubulysin B (HY-N1243) analog with a stable hydrophilic linker. Tub114 can be used for synthesis of ADCs.
    Tub114
  • HY-17664
    Paclitaxel succinate sulfo-NHS ester
    		Inhibitor
    Paclitaxel succinate sulfo-NHS ester is a derivative of Paclitaxel (HY-B0015). Paclitaxel succinate sulfo-NHS ester can be used for the research of cancer.
    Paclitaxel succinate sulfo-NHS ester
  • HY-162264
    Tubulin polymerization/V-ATPase-IN-1
    		Inhibitor
    Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration.
    Tubulin polymerization/V-ATPase-IN-1
  • HY-150511
    3-(3-Phenoxybenzyl)amino-β-carboline
    		Inhibitor
    3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity.
    3-(3-Phenoxybenzyl)amino-β-carboline
  • HY-146818
    Tubulin polymerization-IN-12
    		Inhibitor
    Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells.
    Tubulin polymerization-IN-12
  • HY-146311
    Tubulin polymerization-IN-16
    		Inhibitor
    Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells.
    Tubulin polymerization-IN-16
  • HY-P10790
    Breast cancer targeting peptide 18–4
    		Inhibitor
    Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively.
    Breast cancer targeting peptide 18–4
  • HY-115970
    Tubulin inhibitor 21
    		Inhibitor
    Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells.
    Tubulin inhibitor 21
  • HY-B0736
    Sertaconazole
    		Inhibitor 99.42%
    Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells.
    Sertaconazole
  • HY-158757
    KIF18A-IN-12
    		Inhibitor
    KIF18A-IN-12 (compound 9) is a KIF18A inhibitor, with an IC50 value of 45.54 nM. KIF18A-IN-12 can be used in cancer research.
    KIF18A-IN-12
  • HY-124397
    N-Acetylcolchinol phosphate
    		Inhibitor
    N-Acetylcolchinol phosphate is an inhibitor of tubulin polymerisation. N-Acetylcolchinol phosphate can bind to tubulin cytoskeleton of the endothelial cells in blood vessels of tumor. N-Acetylcolchinol phosphate can be studied in anti-cancer research.
    N-Acetylcolchinol phosphate
Cat. No. Product Name / Synonyms Application Reactivity