STX140

Name: STX140
Brand: MedChemExpress
SKU: HY-133222
Rating: 4.5 (1 reviews)

Cat. No.: HY-133222: Data Sheet Handling Instructions
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STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities.

For research use only. We do not sell to patients.

STX140 Chemical Structure

CAS No. : 401600-86-0

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1 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	0.083 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human DU145 cell line Growth inhibition of human DU145 cell line	[PMID: 17181151]
DU-145	GI₅₀	0.34 μM Compound: 2	Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
DU-145	GI₅₀	0.34 μM Compound: 3	Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay	[PMID: 17696419]
DU-145	GI₅₀	0.34 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 18260615]
HCT-116	GI₅₀	0.045 μM Compound: 2	Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
HCT-116	GI₅₀	0.045 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human HCT116 cell line Growth inhibition of human HCT116 cell line	[PMID: 17181151]
HCT-116	GI₅₀	0.045 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 18260615]
HOP-62	GI₅₀	0.051 μM Compound: 2	Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
HOP-62	GI₅₀	0.051 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human HOP62 cell line Growth inhibition of human HOP62 cell line	[PMID: 17181151]
HOP-62	GI₅₀	0.051 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human HOP62 cells Antiproliferative activity against human HOP62 cells	[PMID: 18260615]
HUVEC	IC₅₀	0.13 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity assessed as inhibition of cord formation in HUVEC Antiangiogenic activity assessed as inhibition of cord formation in HUVEC	[PMID: 17181151]
HUVEC	IC₅₀	0.4 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity in HUVEC by chemotaxis assay Antiangiogenic activity in HUVEC by chemotaxis assay	[PMID: 17181151]
HUVEC	IC₅₀	0.7 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity assessed as growth inhibition in HUVEC Antiangiogenic activity assessed as growth inhibition in HUVEC	[PMID: 17181151]
HUVEC	IC₅₀	44 nM Compound: 3, 2-MeO2bisMATE	Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation	[PMID: 18260615]
MCF7	GI₅₀	0.25 μM Compound: 21, 2-MeOE2bisMATE	Antiproliferative activity against human MCF7 cell line Antiproliferative activity against human MCF7 cell line	[PMID: 17181151]
MCF7	GI₅₀	0.25 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against estrogen receptor positive human MCF7 cells Antiproliferative activity against estrogen receptor positive human MCF7 cells	[PMID: 18260615]
MCF7	IC₅₀	0.25 μM Compound: 15	Antiproliferative activity against estrogen receptor-positive human MCF7 cells Antiproliferative activity against estrogen receptor-positive human MCF7 cells	[PMID: 31255926]
MDA-MB-231	ED₅₀	10 mg/kg Compound: 43	Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily	[PMID: 25992880]
MDA-MB-231	ED₅₀	20 mg/kg Compound: 43	Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly	[PMID: 25992880]
MDA-MB-231	GI₅₀	0.28 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
MDA-MB-231	GI₅₀	0.28 μM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay	[PMID: 17696419]
MDA-MB-231	GI₅₀	0.28 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells	[PMID: 18260615]
MDA-MB-231	IC₅₀	0.29 μM Compound: 15	Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells	[PMID: 31255926]
MDA-MB-435	GI₅₀	< 0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human MDA-MB-435 cell line Growth inhibition of human MDA-MB-435 cell line	[PMID: 17181151]
MDA-MB-435	GI₅₀	< 0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human MDA-MB-435 cells Antiproliferative activity against human MDA-MB-435 cells	[PMID: 18260615]
OVCAR-3	GI₅₀	< 0.01 μM Compound: 2	Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
OVCAR-3	GI₅₀	< 0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human OVCAR-3 cell line Growth inhibition of human OVCAR-3 cell line	[PMID: 17181151]
OVCAR-3	GI₅₀	< 0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human OVCAR-3 cells Antiproliferative activity against human OVCAR-3 cells	[PMID: 18260615]
SF-539	GI₅₀	0.036 μM Compound: 2	Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
SF-539	GI₅₀	0.036 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human SF539 cell line Growth inhibition of human SF539 cell line	[PMID: 17181151]
SF-539	GI₅₀	0.036 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human SF539 cells at Antiproliferative activity against human SF539 cells at	[PMID: 18260615]
SN12C	GI₅₀	0.126 μM Compound: 2	Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay	[PMID: 20225862]
SN12C	GI₅₀	0.126 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human SN12-C cell line Growth inhibition of human SN12-C cell line	[PMID: 17181151]
SN12C	GI₅₀	0.126 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human SN12-C cells Antiproliferative activity against human SN12-C cells	[PMID: 18260615]
UACC-62	GI₅₀	< 0.01 μM Compound: 2	Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
UACC-62	GI₅₀	< 0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human UACC62 cell line Growth inhibition of human UACC62 cell line	[PMID: 17181151]
UACC-62	GI₅₀	< 0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human UACC62 cells Antiproliferative activity against human UACC62 cells	[PMID: 18260615]

In Vitro

STX140 is a potent inhibitor of cell proliferation in a panel of prostate and breast cancer cell lines, with IC₅₀ values of 270 nM, 290 nM, 260 nM, 250 nM, 280 nM, and 44 nM for PC-3, MDA-MB-231, LNCaP, MCF-7, A2780, and HUVEC, respectively^[1].
STX140 (0.5 μM; 24 h) potently induces cell cycle arrest. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	PC-3 cells
Concentration:	0.5 μM
Incubation Time:	24 h
Result:	Potently induced cell cycle arrest with 71% of PC-3 cells being in G2/M after 24 h and 6% in G1.

In Vivo

STX140 (20 mg/kg; p.o.; once daily; 60 days) leads to tumour regression and complete responses, which are maintained after the cessation of dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male MF-1 nu/nu mice injected with PC-3 cells^[1]
Dosage:	20 mg/kg
Administration:	p.o.; once daily; 60 days
Result:	Led to tumour regression and complete responses.

Molecular Weight

460.56

Formula

C₁₉H₂₈N₂O₇S₂

CAS No.

401600-86-0

SMILES

C[C@@]12[C@](CC[C@@H]2OS(N)(=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(OC)=C(OS(N)(=O)=O)C=C4CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S P Newman, et al. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. Br J Cancer. 2007 Dec 17;97(12):1673-82. [Content Brief]

STX140 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX140401600-86-0STX 140STX-140Estrogen Receptor/ERRMicrotubule/TubulinApoptosismicrotubule disruptoranti-angiogenicanti-tumour activitiesapoptosisInhibitorinhibitorinhibit

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STX140

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