SMU-G4

SMU-G4 (multiple concentrations; 48 h) potently inhibits the proliferation of B16-F10, A549, and HepG2 cancer cells with IC₅₀ values of 4 nM, 1.5 nM, and 44.8 nM, respectively^[1].
SMU-G4 (1.5-3 μM) potently inhibits in vitro tubulin polymerization in a concentration-dependent manner, with near-complete suppression at 3 μM^[1].
SMU-G4 (6.25-25 nM; 6 h) dose-dependently disrupts the microtubule network in HepG2 cells after 6 h of treatment^[1].
SMU-G4 (6.25-12.5 nM; 24 h) induces concentration-dependent G₂/M phase cell cycle arrest in B16-F10 cells, with 61.46% of cells in G₂/M phase after 24 h treatment with 12.5 nM^[1].
SMU-G4 (6.25-12.5 nM; 24 h) induces concentration-dependent apoptosis in B16-F10 cells, with 18.90% of cells apoptotic after 24 h treatment with 12.5 nM^[1].
SMU-G4 (1-12 nM; 24 h) dose-dependently increases Cleaved-Caspase 3 expression in B16-F10 cells after 24 h of treatment^[1].
SMU-G4 (6.25-25 nM; 24 h) dose-dependently inhibits B16-F10 cell migration, achieving a 70.78% inhibition rate after 24 h treatment with 25 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.