Tubulin polymerization/V-ATPase-IN-1
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration.
For research use only. We do not sell to patients.
- CAS No.: 3032401-72-9
- Formula: C20H17ClN2O5
- Molecular Weight:400.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.16 μM
Compound: F8
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
|
[PMID: 38336655] |
| DU-145 | IC50 |
0.27 μM
Compound: F8
|
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
|
[PMID: 38336655] |
| MDA-MB-231 | IC50 |
0.21 μM
Compound: F8
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
|
[PMID: 38336655] |
| PC-3 | IC50 |
0.2 μM
Compound: F8
|
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
|
[PMID: 38336655] |
Chemical Information
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CAS No. 3032401-72-9
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Molecular Weight 400.81
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Formula C20H17ClN2O5
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SMILES
COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)