2. Cytoskeleton Cell Cycle/DNA Damage Membrane Transporter/Ion Channel Apoptosis
  3. Microtubule/Tubulin Proton Pump Apoptosis
  4. Tubulin polymerization/V-ATPase-IN-1

Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration.

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Tubulin polymerization/V-ATPase-IN-1

Tubulin polymerization/V-ATPase-IN-1 Chemical Structure

CAS No. : 3032401-72-9

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Tubulin polymerization/V-ATPase-IN-1 Related Antibodies

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Description

Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.16 μM
Compound: F8
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 38336655]
DU-145 IC50
0.27 μM
Compound: F8
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 38336655]
MDA-MB-231 IC50
0.21 μM
Compound: F8
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 38336655]
PC-3 IC50
0.2 μM
Compound: F8
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 38336655]
Molecular Weight

400.81

Formula

C20H17ClN2O5
CAS No.
SMILES

COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization/V-ATPase-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization/V-ATPase-IN-13032401-72-9Microtubule/TubulinProton PumpApoptosiscell apoptosisPC-3 cellsRM-1 homograft model with enhanced T lymphocyte infiltrationInhibitorinhibitorinhibit

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