Tubulin polymerization-IN-12 

Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC₅₀=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells^[1].

Tubulin polymerization-IN-12 (compound 6) shows cytotoxicity against normal human embryonic kidney cells, HEK-293, with an IC₅₀ value of 29.94 μM^[1].
Tubulin polymerization-IN-12 (compound 26) inhibits cancer cells with IC₅₀s of 1.02 μM (A549), 0.75 μM (HeLa), 10.91 μM (HCT116), and 29.94 μM (HEK293), respectively^[2].
Tubulin polymerization-IN-12 (1 μM, 2 μM, 10 μM; 6 h) inhibits tubulin expression in HeLa cell, and shows 42% inhibition at 10 μM^[2].
Tubulin polymerization-IN-12 (0.75 μM-3 μM; 24 h) arrests cell cycle at G2/M phase in HeLa cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

465.46

C₂₃H₂₃N₅O₆

2377301-45-4

COC1=CC(C2=NC3=NC(C)=C(C(N3N2)C4=CC=C(C=C4)[N+]([O-])=O)C(C)=O)=CC(OC)=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang F, et al. Synthesis, and biological evaluation of 3, 6-diaryl-[1, 2, 4] triazolo [4, 3-a] pyridine analogues as new potent tubulin polymerization inhibitors[J]. European Journal of Medicinal Chemistry, 2020, 204: 112625.

  [2]. Yang F, et al. Novel [1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities[J]. Bioorganic Chemistry, 2019, 92: 103260.