2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. DPP-21

DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax).

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DPP-21

DPP-21 화학구조

CAS No. : 2924883-83-8

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DPP-21 Related Antibodies

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제품 설명

DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax)[1].

Cellular Effect
Cell Line Type Value Description References
B16-F10 IC50
11.69 1
Compound: DPP-21
Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
HCT-116 IC50
0.38 1
Compound: DPP-21
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
HeLa IC50
5.37 1
Compound: DPP-21
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
HepG2 IC50
9.37 1
Compound: DPP-21
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
MCF7 IC50
9.53 1
Compound: DPP-21
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
NCI-H23 IC50
8.94 1
Compound: DPP-21
Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay
[PMID: 39197251]
분자량

308.40

화학식

C17H16N4S
CAS No.
SMILES

CC1=NC(N(C2=CC3=C(N(C=C3)C)C=C2)C)=C4SC=CC4=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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DPP-21 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPP-212924883-83-8DPP21DPP 21Microtubule/TubulinApoptosisB16-F10melanomaInhibitorinhibitorinhibit

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DPP-21
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