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Referencia número: HY-146311

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Tubulin polymerization-IN-16

Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells.

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No. CAS: 2296731-38-7
Fòrmula: C₂₄H₂₇N₅O₅
Peso molecular:465.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tubulin polymerization-IN-16 Chemical Structure

No. CAS: 2296731-38-7

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- Cellular Effect
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.133 μM Compound: 5g	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
HeLa	IC₅₀	0.221 μM Compound: 5g	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
SGC-7901	IC₅₀	0.084 μM Compound: 5g	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]

Chemical Information

No. CAS 2296731-38-7
Peso molecular 465.50
Fòrmula C₂₄H₂₇N₅O₅
SMILES

COC1=CC(C(C2=NN(N=C2N3CCN(CC3)C(C)=O)C4=CC=CC=C4)=O)=CC(OC)=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Tubulin polymerization-IN-16

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Tubulin polymerization-IN-16

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Tubulin polymerization-IN-16 Related Classifications

HY-146311 Related Classifications