2296731-38-7
Chemical Structure
Tubulin polymerization-IN-16
- CAS No.: 2296731-38-7
- Formula:C24H27N5O5
- Molecular Weight:465.50
IUPAC Name: 1-(4-(2-phenyl-5-(3,4,5-trimethoxybenzoyl)-2H-1,2,3-triazol-4-yl)piperazin-1-yl)ethan-1-one
InChIKey: FLVGDYBZNPGUNX-UHFFFAOYSA-N
SMILES: COC1=CC(C(C2=NN(N=C2N3CCN(CC3)C(C)=O)C4=CC=CC=C4)=O)=CC(OC)=C1OC
Biological Activity: Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells[1].
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Tubulin polymerization-IN-16 | Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells. | |||||||||||||||||||||
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Keywords
