Tubulin polymerization-IN-62
Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC50 is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model.
For research use only. We do not sell to patients.
- Formula: C37H44N4O4
- Molecular Weight:608.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 608.77
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Formula C37H44N4O4
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SMILES
O=C(CC1=NC=C(C2=CC=C(OCCNC(CCCC(NC3[C@@H]4C[C@@H]5C[C@H]3C[C@@H](C5)C4)=O)=O)C=C2)C=C1)NCC6=CC=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-62 Related Classifications
HY-161641 Related Classifications
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