1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Glutaric acid

Glutaric acid 

Cat. No.: HY-W008820 Purity: >98.0%
Handling Instructions

Glutaric acid induces oxidative stress in brain of young rats.

For research use only. We do not sell to patients.

Glutaric acid Chemical Structure

Glutaric acid Chemical Structure

CAS No. : 110-94-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Glutaric acid induces oxidative stress in brain of young rats.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].

Molecular Weight

132.12

Formula

C₅H₈O₄

CAS No.

110-94-1

SMILES

O=C(O)CCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (946.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5689 mL 37.8444 mL 75.6888 mL
5 mM 1.5138 mL 7.5689 mL 15.1378 mL
10 mM 0.7569 mL 3.7844 mL 7.5689 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (15.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (15.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (15.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Glutaric acid
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HY-W008820
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