12-Hydroxystearic acid

Name: 12-Hydroxystearic acid
Brand: MedChemExpress
SKU: HY-W127329
Rating: 4.5 (1 reviews)

Cat. No.: HY-W127329 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

12-Hydroxystearic acid is a structurally simple and cost-effective low molecular weight organogelator, and its metal salts and derivatives find roles in many important applications.

For research use only. We do not sell to patients.

12-Hydroxystearic acid Chemical Structure

CAS No. : 106-14-9

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 12-Hydroxystearic acid:

12-Hydroxystearic acid-d₅ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

12-Hydroxystearic acid is a structurally simple and cost-effective low molecular weight organogelator, and its metal salts and derivatives find roles in many important applications^[1]^[2].

In Vitro

12-Hydroxystearic acid (12HSA) and its derivatives have been studied in great detail due to it is effectiveness as a gelator and utility in lubricants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.48

Formula

C₁₈H₃₆O₃

CAS No.

106-14-9

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCC(CCCCCCCCCCC(=O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (332.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3280 mL	16.6400 mL	33.2801 mL
5 mM	0.6656 mL	3.3280 mL	6.6560 mL
10 mM	0.3328 mL	1.6640 mL	3.3280 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (265 KB) SDS (392 KB)

COA (238 KB) HNMR (124 KB)

Handling Instructions (2659 KB)

References

[1]. Gordon R, et al. Aggregation of 12-Hydroxystearic Acid and Its Lithium Salt in Hexane: Molecular Dynamics Simulations. J Phys Chem B. 2016;120(29):7164-7173. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3280 mL	16.6400 mL	33.2801 mL	83.2002 mL
	5 mM	0.6656 mL	3.3280 mL	6.6560 mL	16.6400 mL
	10 mM	0.3328 mL	1.6640 mL	3.3280 mL	8.3200 mL
	15 mM	0.2219 mL	1.1093 mL	2.2187 mL	5.5467 mL
	20 mM	0.1664 mL	0.8320 mL	1.6640 mL	4.1600 mL
	25 mM	0.1331 mL	0.6656 mL	1.3312 mL	3.3280 mL
	30 mM	0.1109 mL	0.5547 mL	1.1093 mL	2.7733 mL
	40 mM	0.0832 mL	0.4160 mL	0.8320 mL	2.0800 mL
	50 mM	0.0666 mL	0.3328 mL	0.6656 mL	1.6640 mL
	60 mM	0.0555 mL	0.2773 mL	0.5547 mL	1.3867 mL
	80 mM	0.0416 mL	0.2080 mL	0.4160 mL	1.0400 mL
	100 mM	0.0333 mL	0.1664 mL	0.3328 mL	0.8320 mL