2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108601
    (S)-Ro 32-0432 free base
    		Inhibitor
    (S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research.
    (S)-Ro 32-0432 free base
  • HY-RS11137
    PRKCQ Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCQ Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCQ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCQ Human Pre-designed siRNA Set A
  • HY-RS11135
    Prkci Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkci Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkci gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkci Mouse Pre-designed siRNA Set A
  • HY-118384R
    Sangivamycin (Standard)
    		Inhibitor
    Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
    Sangivamycin (Standard)
  • HY-105517
    MDL 27032
    		Inhibitor
    MDL 27032 is an active site-directed inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with Ki values of 24 and 14.3μM. MDL 27032 can relaxe vascular smooth muscle and can be used as vasodilator.
    MDL 27032
  • HY-RS11117
    Prkca Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkca Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkca gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkca Mouse Pre-designed siRNA Set A
  • HY-N0152R
    Myricitrin (Standard)
    		Inhibitor
    Myricitrin (Standard) is the analytical standard of Myricitrin. This product is intended for research and analytical applications. Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects.
    Myricitrin (Standard)
  • HY-P10821
    Myr-Tat-PKCβII
    		Inhibitor
    Myr-Tat-PKCβII is a cell permeable protein kinase C β II peptide inhibitor. Myr-Tat-PKCβII mitigates the generation of reactive oxygen species in rat ex-vivo and porcine in-vivo ischemia-reperfusion injury.
    Myr-Tat-PKCβII
  • HY-P3786
    H-Arg-Gly-Tyr-Ala-Leu-Gly-OH
    		Inhibitor
    H-Arg-Gly-Tyr-Ala-Leu-Gly-OH is a competitive and CAMP dependent protein kinase inhibitor.
    H-Arg-Gly-Tyr-Ala-Leu-Gly-OH
  • HY-169006
    Evo312
    		Inhibitor
    Evo312 is a dose-dependent inhibitor of protein kinase CβⅠ (PKCβⅠ) (IC50 is 117.34 nM). Evo312 induces PANC-GR (acquired gemcitabine-resistant PC cells) cell cycle arrest and apoptosis by inhibiting PKCβ1 protein expression. Evo312 has antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR cells with IC50 of 0.08 μM and 0.07 μM, and in human normal pancreatic ductal epithelial cells HPDE6-c7 with IC50 of 2.95 μM. Evo312 exhibits antitumor activity in a PANC-GR cell transplantation mouse model.
    Evo312
  • HY-P5439
    Epsilon-V1-2, Cys-conjugated
    		Inhibitor
    Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
    Epsilon-V1-2, Cys-conjugated
  • HY-P5885
    PKCη pseudosubstrate inhibitor,myristoylated
    		Inhibitor
    PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη.
    PKCη pseudosubstrate inhibitor,myristoylated
  • HY-10539B
    Enzastaurin hydrochloride
    		Inhibitor
    Enzastaurin (LY317615) hydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.
    Enzastaurin hydrochloride
  • HY-135254
    CP-46665 dihydrochloride
    		Inhibitor
    CP-46665 dihydrochloride is an anticancer agent that inhibits the incorporation of tritiated thymidine into leukemia cells and human solid tumor cells in vitro. It can lead to the loss of surface characteristics in tumor cells and disrupt cell membranes, inhibiting cell proliferation.
    CP-46665 dihydrochloride
  • HY-RS11120
    Prkcb Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcb Mouse Pre-designed siRNA Set A
  • HY-P1289D
    [Ala107]MBP(104-118) acetate
    		Inhibitor
    [Ala107]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 46-145 μM.
    [Ala107]MBP(104-118) acetate
  • HY-10539
    Enzastaurin dihydrochloride
    		Inhibitor
    Enzastaurin (LY317615) dihydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.
    Enzastaurin dihydrochloride
  • HY-124308
    PS315
    		Inhibitor
    PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity.
    PS315
  • HY-162234
    PKCTheta-IN-1
    		Inhibitor
    PKCTheta-IN-1 (Compound 19) is a selective macrocyclic PKCTheta inhibitor with IC50 value of 0.1 nM.
    PKCTheta-IN-1
  • HY-177283
    PKC-IN-7
    		Inhibitor
    PKC-IN-7 is an inhibitor of PKC. PKC-IN-7 can be used in the research of diseases such as cancer.
    PKC-IN-7
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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