PPAR
Peroxisome proliferator-activated receptors
PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.
PPAR Isoform Specific Products
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PPAR Inhibitors
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PPAR Agonists
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PPAR Antagonists
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PPAR Activators
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PPAR Modulators
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PPAR Inducers
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PPAR Controls
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PPAR Ligands
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Peroxisome Proliferator-activated Receptor Proteins
(11)
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PPAR alpha Proteins
(2)
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PPAR gamma Proteins
(7)
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PPAR-delta Proteins
(2)
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PPAR Related Products (737)
Related Products (737)
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Recombinant Proteins (11)
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Antibodies (4)
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PPAR Isoform Comparison
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9(S)-HOTrE
0 Images9(S)-HOTrE is a PPARα activator and an inducer of apolipoprotein A-I (apoA-I) mRNA expression. 9(S)-HOTrE upregulates the expression of PPARα target gene CPT1α. 9(S)-HOTrE can be used in the research of cardiovascular diseases.
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Procyanidin C2
0 ImagesCat. No.: HY-N7521CAS No.: 37064-31-6Synonyms: Procyanidine C2Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated AMPKα and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease.
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Raspberry ketone (Standard)
0 ImagesSynonyms: Frambione (Standard); 4-(4-Hydroxyphenyl)-2-butanone (Standard)Raspberry ketone (Standard) is the analytical standard of Raspberry ketone. This product is intended for research and analytical applications. Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
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Sodium propionate-d5
0 ImagesSodium propionate-d5 is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
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Seladelpar (lysine)
0 ImagesSynonyms: MBX-8025 (lysine); RWJ-800025 (lysine)Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis.
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GW 501516 (Standard)
0 ImagesSynonyms: GW 1516 (Standard); GSK-516 (Standard)GW 501516 (Standard) is the analytical standard of GW 501516. This product is intended for research and analytical applications. GW 501516 (GW 1516) is a PPARδ agonist with an EC50 of 1.1 nM.
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5-Aminosalicylic acid-13C6 hydrochloride
0 ImagesSynonyms: Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
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Naveglitazar racemate
0 ImagesCat. No.: HY-U00036CAS No.: 916085-47-7Synonyms: LY519818 racemateNaveglitazar racemate (LY519818 racemate) is the racemate of Naveglitazar. Naveglitazar is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering potential in animal models.
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Arhalofenate
0 ImagesSynonyms: MBX 102; JNJ 39659100Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes.
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Pioglitazone (Standard)
0 ImagesSynonyms: U 72107 (Standard)Pioglitazone (Standard) is the analytical standard of Pioglitazone. This product is intended for research and analytical applications. Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research.
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Triumbelletin
0 ImagesTriumbelletin is a tricoumarin rhamnopyranoside that can be found in Daphne mezereum.
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Octocrylene (Standard)
0 ImagesOctocrylene (Standard) is the analytical standard of Octocrylene. This product is intended for research and analytical applications. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. Octocrylene has the potential for using in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation.
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Norbixin
0 ImagesCat. No.: HY-W587784CAS No.: 542-40-5Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H2O2-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye.
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PPARα agonist 2
0 ImagesCat. No.: HY-139177CAS No.: 2376590-40-6PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research.
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Rosiglitazone potassium
0 ImagesSynonyms: BRL 49653 potassium
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Pparδ agonist 5
0 ImagesCat. No.: HY-141494Pparδ agonist 5, an orally active PPARδ-selective agonist (EC50=0.335 μM), is much greater than that of the prototypical standard GW0742. Pparδ agonist 5 promotes improvements in bone density and microarchitecture in vivo.
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ABP/PPAR modulator 1
0 ImagesCat. No.: HY-172883CAS No.: 3104894-76-7ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model.
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MK-886 sodium salt
0 ImagesCat. No.: HY-14166ACAS No.: 118427-55-7Synonyms: L 663536 sodium saltMK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis.
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Seladelpar (lysine dihydrate)
0 ImagesSynonyms: MBX-8025 (lysine dihydrate); RWJ-800025 (lysine dihydrate)Seladelpar Lysine dihydrate (MBX-8025 lysine dihydrate) is an orally active, selective PPAR-δ agonist with an EC50 of 2 nM against hPPAR-δ. Seladelpar Lysine dihydrate reduces serum IL-31 and bile acid levels. It alleviates pruritus symptoms. Seladelpar Lysine dihydrate enhances insulin sensitivity, normalizes levels of hyperglycemia, hyperinsulinemia, glucose disposal capacity, serum lipids and hepatic free cholesterol. It reduces steatosis, hepatic inflammation and improves liver fibrosis. Seladelpar Lysine dihydrate reverses the pathological changes of non-alcoholic steatohepatitis (NASH). It is applicable to research related to primary biliary cholangitis and non-alcoholic steatohepatitis (NASH).
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Pioglitazone potassium
0 ImagesCat. No.: HY-13956BCAS No.: 1266523-09-4Synonyms: U 72107 potassiumPioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium can be used in diabetes research.
