2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Inolitazone hydrochloride hydrate

Inolitazone hydrochloride hydrate  (Synonyms: Efatutazone hydrochloride hydrate; CS-7017 hydrochloride hydrate; RS5444 hydrochloride hydrate)

Cat. No.: HY-14792C
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Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer.

For research use only. We do not sell to patients.

CAS No. : 1048002-36-3

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Inolitazone hydrochloride hydrate Related Antibodies

Top Publications Citing Use of Products

    Inolitazone hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 May;7(5):1955-1966.  [Abstract]

    Protein expression in cells incubated with 40 μM Efatutazone for 12, 24, and 48 h.

    Inolitazone hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2017 Dec 15;361(2):246-256.  [Abstract]

    Western blot analysis for p21, p-p21, Cyclin D1. Bcl-2, Caspase 3, Cleaved Caspase 3, Caspase 9, Cleaved Caspase 9 and Bax in HCC827-GR and PC-9-GR cells treated with control, Efatutazone alone, Gefitinib alone, or Efatutazone combined with gefitinib for 48 h.

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    PPARα PPARβ/δ PPARγ PPAR PPARδ

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    Description

    Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer[1][2].

    IC50 & Target[1]

    PPARγ

     

    Molecular Weight

    593.52

    Formula

    C27H30Cl2N4O5S
    CAS No.
    SMILES

    CC1=C(N)C(C)=CC(OC2=CC(N(C)C(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)=N5)=C5C=C2)=C1.O.Cl.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Inolitazone hydrochloride hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Inolitazone hydrochloride1048002-36-3Efatutazone hydrochlorideCS-7017 hydrochlorideRS5444 hydrochloridePPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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