Inolitazone hydrochloride hydrate
Based on 5 publication(s) in Google Scholar
Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone (HY-17386), and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1048002-36-3
- Formula: C27H30Cl2N4O5S
- Molecular Weight:593.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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PPARγ |
Chemical Information
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CAS No. 1048002-36-3
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Molecular Weight 593.52
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Formula C27H30Cl2N4O5S
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SMILES
CC1=C(N)C(C)=CC(OC2=CC(N(C)C(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)=N5)=C5C=C2)=C1.O.Cl.Cl
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Synonyms
Efatutazone hydrochloride hydrate; CS-7017 hydrochloride hydrate; RS5444 hydrochloride hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Int J Oncol
2018 Jun;52(6):1991-2000. PMID: 29620161 -
Front Microbiol
Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes. [Abstract]2019 Jan 8:9:3257. PMID: 30671048 -
Cancer Med
Efatutazone and T0901317 exert synergistically therapeutic effects in acquired gefitinib-resistant lung adenocarcinoma cells. [Abstract]2018 May;7(5):1955-1966. PMID: 29573196
Inolitazone hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 May;7(5):1955-1966. [Abstract]
Protein expression in cells incubated with 40 μM Efatutazone for 12, 24, and 48 h.
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Exp Cell Res
PPARγ agonist efatutazone and gefitinib synergistically inhibit the proliferation of EGFR-TKI-resistant lung adenocarcinoma cells via the PPARγ/PTEN/Akt pathway. [Abstract]2017 Dec 15;361(2):246-256. PMID: 29080795
Inolitazone hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2017 Dec 15;361(2):246-256. [Abstract]
Western blot analysis for p21, p-p21, Cyclin D1. Bcl-2, Caspase 3, Cleaved Caspase 3, Caspase 9, Cleaved Caspase 9 and Bax in HCC827-GR and PC-9-GR cells treated with control, Efatutazone alone, Gefitinib alone, or Efatutazone combined with gefitinib for 48 h.
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Purity & Documentation
References
[1]. Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17. [Content Brief]
[2]. Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Inolitazone hydrochloride hydrate Related Classifications
HY-14792C Related Classifications
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