Tyrosinase

Related Products

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (301)
Antibodies (9)

By Effects:	Inhibitors (259) Degrader (1) Substrates (6) Antagonist (1) Activators (10) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-119152

CMX-2043	Activator	98.80%
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model.

HY-N2413

Gomisin D	Inhibitor	99.56%
Gomisin D is an orally active lignan that binds to PDGFRβ with a K_d of 10 μM. By targeting PDGFRβ to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimer's disease, and hepatic fibrosis.

HY-N7929

5-Feruloylquinic acid	Inhibitor	99.73%
5-Feruloylquinic acid (5-FQA) is a hydroxycinnamic acid derivative. 5-Feruloylquinic acid can be isolated from green coffee beans. 5-Feruloylquinic acid inhibits tyrosinase activity. 5-Feruloylquinic acid has antioxidant properties. 5-Feruloylquinic acid has anticancer activity against lymphoma, oral epidermal cancer, and breast cancer.

HY-W013636B

Calcium 2-oxoglutarate	Inhibitor	98.0%
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-113404

DL-Dopa	Substrate	98.58%
DL-Dopa is a dopamine precursor. It serves as a substrate for Mushroom Tyrosinase, which oxidizes it to dopaquinone, an intermediate in the DOPA-melanin polymerization process, and this reaction can be detected at 475 nm. DL-Dopa also forms synergistic hydrophobic and π-π stacking interactions with cationic surfactants. Its binding to cetylpyridinium chloride (HY-B1464) is stronger and exhibits better thermodynamic stability than its binding to benzalkonium chloride (HY-B2232). DL-Dopa can compensate for dopamine depletion in the brain and is applicable to research related to Parkinson's disease.

HY-N2134

Mirificin	Inhibitor	99.66%
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM.

HY-W115529

Geranic acid	Inhibitor
Geranic acid (Geranate) acts as a tyrosinase inhibitor and antifungal agent, with an IC₅₀ value of 0.14-2.3 mM against mushroom tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma.

HY-101243

XMD16-5	Inhibitor	98.20%
XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

HY-P10533

Cysteine peptide	Inhibitor	99.74%
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses.

HY-W015616

Benzylacetone	Inhibitor	99.78%
Benzylacetone (4-Penylbutan-2-one) is an aromatic compound. Benzylacetone is a mushroom tyrosinase inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults.

HY-N2101

Benzoyloxypaeoniflorin	Inhibitor	98.60%
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-145587

Paltimatrectinib	Inhibitor	99.95%
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC₅₀ of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases.

HY-N1098

Velutin	Inhibitor	98.60%
Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration.

HY-N1386

2-Methoxycinnamic acid	Inhibitor	99.94%
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.

HY-N1780

3,4-Dimethoxyphenol	Inhibitor	99.97%
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Inhibitor	99.46%
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive Tyrosinase inhibitor. It exhibits an IC₅₀ value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC₅₀ value of 62 μM with DL-DOPA as the substrate, and a K_i value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation.

HY-N2135

Puerarin 6''-O-Xyloside	Inhibitor	99.81%
Puerarin 6''-O-Xyloside is one of the major iso-flavones found in P. lobata. Puerarin 6''-O-Xyloside inhibits cancer cells proliferation, induces apoptosis by upregulating cleaved caspase-3, 7, 9, Bax and downregulating Bcl-2 levles and inhibits tumor growth in mice. Puerarin 6''-O-Xyloside has anti-osteoporotic activity in ovariectomized mice. Puerarin 6''-O-Xyloside inhibits mushroom tyrosinase with an IC₅₀ of 513.8 μM. Puerarin 6''-O-Xyloside can be used for the research of human lung carcinoma, osteoporosis, melanosis and melanomar.

HY-W007671

H-Tyr-OMe	Substrate	99.92%
H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols.

HY-W013852

PKC-IN-6	Inhibitor	99.93%
PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against PKC-α, PKC-δ, PKA, EGF-R with IC₅₀ values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers.

HY-W013636S1

2-Ketoglutaric acid-d₄
2-Ketoglutaric acid-d₄ (Alpha-Ketoglutaric acid-d₄) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (301)

Antibodies (9)

Tyrosinase Related Products (301):