Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (546)
Related Products (546)
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(R,R)-S63845
0 ImagesCat. No.: HY-100741CPurity: 99.32%
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rel-VU6021625
0 Imagesrel-VU6021625 is the relative configuration of VU6021625 (HY-160440A). VU6021625 is a potent and selective mAChR M4 antagonist with IC50 values of 0.44 nM and 57 nM for human M4, rat M4, respectively.
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(E)-Ethyl cinnamate
0 Images(E)-Ethyl cinnamate is an isomer of Ethyl cinnamate (HY-Y0121), a cinnamate ester, and a plant secondary metabolite. (E)-Ethyl cinnamate exists in cinnamon, Artemisia pallens, and various other plants. (E)-Ethyl cinnamate exhibits acaricidal activity.
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(±)-Lavandulyl acetate
0 Images(±)-Lavandulyl acetate is an isomer of (-)-Lavandulyl acetate (HY-117419). (-)-Lavandulyl acetate is a nature product that can be found in Lavandula angustifolia. (-)-Lavandulyl acetate shows toxicity for mosquito vectors. (-)-Lavandulyl acetate can be used as mosquito larvicide.
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cis-Isoeugenol
0 Imagescis-Isoeugenol is the cis isomer of Isoeugenol (HY-N1952).
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(R)-Zelebrudomide
0 ImagesSynonyms: (R)-NX-2127(R)-Zelebrudomide ((R)-NX-2127) is an isomer of Zelebrudomide (HY-153220). Zelebrudomide is an orally active BTK-targeting PROTAC degrader, with DC50 values of 4.5 nM and 31 nM against wild-type BTK and BTKC481S mutant, respectively. Zelebrudomide recruits the cereblon E3 ubiquitin ligase complex to mediate the degradation of BTK. Zelebrudomide also acts as a molecular glue to bind the cereblon E3 ubiquitin ligase complex, mediating the degradation of IKZF1 and IKZF3. Zelebrudomide can be used in the research of B-cell malignancies.
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(±) Anabasine
0 Images(±) Anabasine is the racemic form of Anabasine (HY-B1532). (±) Anabasine stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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Bazedoxifene acetate-B
0 ImagesCat. No.: HY-A0036BCAS No.: 198481-33-3Synonyms: TSE-424 acetate-BBazedoxifene (acetate)-B (TSE-424 (acetate)-B) is the B-crystal form compound of Bazedoxifene acetate (HY-A0036).
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(R,S,R)-ML334
0 ImagesSynonyms: (R,S,R)-LH601A(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.
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(R)-Filanesib
0 ImagesSynonyms: (R)-ARRY-520(R)-Filanesib ((R)-ARRY-520) is an isomer of Filanesib (HY-15187). Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.
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(R)-mchm5U
0 Images(R)-mchm5U is a diastereomer of (S)-mchm5U (HY-153100A).
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Viquidil hydrochloride
0 ImagesSynonyms: Quinotoxine hydrochlorideViquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity.
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(Rac)-LM11A-31 dihydrochloride
0 Images(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist.
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(±)-Levomepromazine
0 ImagesSynonyms: (±)-Methotrimeprazine; dl-Methotrimeprazine(±)-Levomepromazine ((±)-Methotrimeprazine) is the racemate of Levomepromazine (HY-B1693).
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(R)-Elexacaftor
0 ImagesSynonyms: (R)-VX-445(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis.
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4α-Hydroxycholesterol
0 Images4α-Hydroxycholesterol is an isomer of 4β-Hydroxycholesterol (HY-124265). 4α-Hydroxycholesterol has a slight effect on the integrity of lysosomal membranes in mouse primary oligodendrocyte cultures.
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Praeruptorin A
0 ImagesSynonyms: (+)-Praeruptorin APraeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension.
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(Z)-JIB-04
0 ImagesSynonyms: NSC693627
