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  4. (R)-PF-04991532

(R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.

For research use only. We do not sell to patients.

(R)-PF-04991532 Chemical Structure

(R)-PF-04991532 Chemical Structure

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 210 In-stock
25 mg USD 420 In-stock
50 mg USD 710 In-stock
100 mg USD 1200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-PF-04991532:

(R)-PF-04991532 Related Antibodies

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Description

(R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.

Molecular Weight

396.36

Formula

C18H19F3N4O3
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NC([C@H](N2C=C(C(F)(F)F)N=C2)CC3CCCC3)=O)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (252.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5230 mL 12.6148 mL 25.2296 mL
5 mM 0.5046 mL 2.5230 mL 5.0459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

COA (251 KB) HNMR (287 KB) LCMS (251 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5230 mL 12.6148 mL 25.2296 mL 63.0740 mL
5 mM 0.5046 mL 2.5230 mL 5.0459 mL 12.6148 mL
10 mM 0.2523 mL 1.2615 mL 2.5230 mL 6.3074 mL
15 mM 0.1682 mL 0.8410 mL 1.6820 mL 4.2049 mL
20 mM 0.1261 mL 0.6307 mL 1.2615 mL 3.1537 mL
25 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.5230 mL
30 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
40 mM 0.0631 mL 0.3154 mL 0.6307 mL 1.5768 mL
50 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.2615 mL
60 mM 0.0420 mL 0.2102 mL 0.4205 mL 1.0512 mL
80 mM 0.0315 mL 0.1577 mL 0.3154 mL 0.7884 mL
100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.6307 mL
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(R)-PF-04991532 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-PF-04991532OthersR-enantiomerPF-04991532Inhibitorinhibitorinhibit

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