(R)-PF-04991532
Based on 1 Customer Validation
(R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.
For research use only. We do not sell to patients.
- Purity: 98.04%
- Formula: C18H19F3N4O3
- Molecular Weight:396.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 396.36
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Formula C18H19F3N4O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(NC([C@H](N2C=C(C(F)(F)F)N=C2)CC3CCCC3)=O)N=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (252.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5230 mL | 12.6148 mL | 25.2296 mL | 63.0740 mL |
| 5 mM | 0.5046 mL | 2.5230 mL | 5.0459 mL | 12.6148 mL | |
| 10 mM | 0.2523 mL | 1.2615 mL | 2.5230 mL | 6.3074 mL | |
| 15 mM | 0.1682 mL | 0.8410 mL | 1.6820 mL | 4.2049 mL | |
| 20 mM | 0.1261 mL | 0.6307 mL | 1.2615 mL | 3.1537 mL | |
| 25 mM | 0.1009 mL | 0.5046 mL | 1.0092 mL | 2.5230 mL | |
| 30 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1025 mL | |
| 40 mM | 0.0631 mL | 0.3154 mL | 0.6307 mL | 1.5768 mL | |
| 50 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2615 mL | |
| 60 mM | 0.0420 mL | 0.2102 mL | 0.4205 mL | 1.0512 mL | |
| 80 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7884 mL | |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.6307 mL |