1. Metabolic Enzyme/Protease
  2. Proteasome
  3. (1S,2S)-Bortezomib

(1S,2S)-Bortezomib 

Cat. No.: HY-135396
Handling Instructions

(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans.

For research use only. We do not sell to patients.

(1S,2S)-Bortezomib Chemical Structure

(1S,2S)-Bortezomib Chemical Structure

CAS No. : 1132709-14-8

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Description

(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3].

IC50 & Target

Ki: 0.6 nM (20S proteasome)[1]

Molecular Weight

384.24

Formula

C₁₉H₂₅BN₄O₄

CAS No.

1132709-14-8

SMILES

OB([[email protected]](NC([[email protected]@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O)CC(C)C)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(1S,2S)-BortezomibProteasomeBortezomibenantiomerproteasomeNF-κBanti-cancerInhibitorinhibitorinhibit

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(1S,2S)-Bortezomib
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HY-135396
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