2. PI3K/Akt/mTOR Others
  3. PI3K Drug Isomer
  4. (S)-Zovegalisib

(S)-Zovegalisib  (Synonyms: (S)-RLY-2608)

Cat. No.: HY-153306A Purity: 99.89%
COA
SDS
Handling Instructions Technical Support

(S)-Zovegalisib ((S)-RLY-2608) is an S-enantiomer of of Zovegalisib (HY-153306). Zovegalisib is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity.

For research use only. We do not sell to patients.

(S)-Zovegalisib

(S)-Zovegalisib Chemical Structure

CAS No. : 2733573-93-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Other Forms of (S)-Zovegalisib:

(S)-Zovegalisib Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

(S)-Zovegalisib ((S)-RLY-2608) is an S-enantiomer of of Zovegalisib (HY-153306). Zovegalisib is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity[1].

Molecular Weight

608.91

Formula

C29H14ClF5N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N[C@H](C2=CC(F)=CC=C2Cl)C(C1=C3)=C(NC(C4=CC(F)=CC(C(F)(F)F)=C4)=O)C=C3C5=C(C#N)N6C(C=C5)=NC=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (65.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6423 mL 8.2114 mL 16.4228 mL
5 mM 0.3285 mL 1.6423 mL 3.2846 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.89%

SDS (393 KB)

COA (259 KB) HNMR (314 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6423 mL 8.2114 mL 16.4228 mL 41.0570 mL
5 mM 0.3285 mL 1.6423 mL 3.2846 mL 8.2114 mL
10 mM 0.1642 mL 0.8211 mL 1.6423 mL 4.1057 mL
15 mM 0.1095 mL 0.5474 mL 1.0949 mL 2.7371 mL
20 mM 0.0821 mL 0.4106 mL 0.8211 mL 2.0528 mL
25 mM 0.0657 mL 0.3285 mL 0.6569 mL 1.6423 mL
30 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3686 mL
40 mM 0.0411 mL 0.2053 mL 0.4106 mL 1.0264 mL
50 mM 0.0328 mL 0.1642 mL 0.3285 mL 0.8211 mL
60 mM 0.0274 mL 0.1369 mL 0.2737 mL 0.6843 mL
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(S)-Zovegalisib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Zovegalisib2733573-93-6(S)-RLY-2608PI3KDrug IsomerPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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