mGluR
Metabotropic glutamate receptors
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.
mGluR Isoform Specific Products
All Product Categories
-
mGluR Related Products (400)
Related Products (400)
-
Antibodies (8)
-
mGluR Isoform Comparison
-
3-MATIDA
0 ImagesCat. No.: HY-103563CAS No.: 518357-51-23-MATIDA is a metabolic glutamate 1 (mGlu1) receptor antagonist. 3-MATIDA alleviates neuronal death in cerebral ischemia models. 3-MATIDA can be used in the study of neuronal injury and epileptiform activity after ischemia .
-
NSC 303861
0 ImagesCat. No.: HY-105916CAS No.: 51785-99-0NSC 303861 is an L-glutamine receptor antagonist. NSC 303861 selectively inhibits glutamine dependent enzymes in purine nucleotide synthesis without affecting pyrimidine synthase. NSC 303861 has significant cytotoxicity against liver cancer 3924A cells (LC50 = 6 µM). NSC 303861 can be used for cancer research.
-
LY2934747
0 ImagesCat. No.: HY-131288CAS No.: 1448707-43-4LY2934747 is a selective and blood-brain barrier-permeable dual mGlu2/mGlu3 receptor agonist, with Ki values of 260 nM and 177 nM, and EC50 values of 8.4 nM and 62.4 nM against human receptors, respectively. LY2934747 exhibits antipsychotic and analgesic activities in in vivo animal models. LY2934747 can be used in studies related to psychosis and pain.
-
(S)-MCPG (Standard)
0 ImagesCat. No.: HY-100406RCAS No.: 150145-89-4Synonyms: (+)-MCPG (Standard)(S)-MCPG (Standard) is the analytical standard of (S)-MCPG (HY-100406). This product is intended for research and analytical applications. (S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.
-
JNJ16259685 (Standard)
0 ImagesCat. No.: HY-100407RCAS No.: 409345-29-5JNJ16259685 (Standard) is the analytical standard of JNJ16259685 (HY-100407). This product is intended for research and analytical applications. JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
-
Fenobam (Standard)
0 ImagesCat. No.: HY-101478RCAS No.: 57653-26-6Fenobam (Standard) is the analytical standard of Fenobam. This product is intended for research and analytical applications. Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction.
-
DFMTI (Standard)
0 ImagesCat. No.: HY-100404RCAS No.: 864864-86-8Synonyms: MK5435 (Standard)DFMTI (Standard) (MK5435 (Standard)) is the analytical standard of DFMTI (HY-100404). This product is intended for research and analytical applications. DFMTI is a blood-brain barrier-penetrant mGluR1 inhibitor. DFMTI abolishes the tobacco mosaic virus (TMV) resistance phenotype of NbAS-B-overexpressing plants by inhibiting glutamate production required for the activation of the Salicylic acid (HY-B0167) pathway. DFMTI disrupts prepulse inhibition in rats. DFMTI can be used in research related to psychiatric disorders and tobacco mosaic virus infection.
-
(RS)-PPG (Standard)
0 ImagesCat. No.: HY-107514RCAS No.: 120667-15-4(RS)-PPG (Standard) is the analytical standard of (RS)-PPG (HY-107514). This product is intended for research and analytical applications. (RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity.
-
Raseglurant hydrochloride (Standard)
0 ImagesCat. No.: HY-103574RCAS No.: 757949-98-7Synonyms: ADX-10059 hydrochloride (Standard)Raseglurant hydrochloride (Standard) is the analytical standard of Raseglurant hydrochloride (HY-103574). This product is intended for research and analytical applications. Raseglurant hydrochloride is a negative allosteric modulator of mGluR5. Raseglurant hydrochloride can be used in study migraine.
-
CFMMC
0 ImagesCat. No.: HY-116723CAS No.: 1190598-60-7CFMMC is a selective allosteric metabotropic glutamate receptor 1 (mGluR1) antagonist. CFMMC inhibits L-glutamate-induced intracellular Ca2+ mobilization ([Ca2+]i) in Chinese hamster ovary cells expressing recombinant human mGluR1a with an IC50 value of 50 nM. CFMMC is promising for research of various central nervous system disorders, such as schizophrenia, epilepsy, anxiety, pain, cognitive dysfunction and drug abuse.
-
MFZ 10-7 (Standard)
0 ImagesCat. No.: HY-103575RCAS No.: 1224431-15-5MFZ 10-7 (Standard) is the analytical standard of MFZ 10-7 (HY-103575). This product is intended for research and analytical applications. MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
YM-230888
0 ImagesCat. No.: HY-107510CAS No.: 446257-23-4YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models.
-
MNI137 (Standard)
0 ImagesCat. No.: HY-103572RCAS No.: 946619-21-2MNI137 (Standard) is the analytical standard of MNI137 (HY-103572). This product is intended for research and analytical applications. MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.
-
LY367385 hydrochloride (Standard)
0 ImagesCat. No.: HY-107515ARCAS No.: 2829282-00-8LY367385 hydrochloride (Standard) is the analytical standard of LY367385 (hydrochloride) (HY-107515A). This product is intended for research and analytical applications. LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects.
-
NCFP
0 ImagesCat. No.: HY-123667CAS No.: 774548-65-1NCFP is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM). NCFP can be used in the study of central nervous system diseases.
-
CHPG sodium salt (Standard)
0 ImagesCHPG (sodium salt) (Standard) is the analytical standard of CHPG (sodium salt). This product is intended for research and analytical applications. CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..
-
MMPIP hydrochloride (Standard)
0 ImagesCat. No.: HY-103111RCAS No.: 1215566-78-1MMPIP hydrochloride (Standard) is the analytical standard of MMPIP hydrochloride (HY-103111). This product is intended for research and analytical applications. MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.
-
AZD-8529 mesylate (Standard)
0 ImagesCat. No.: HY-107457ARCAS No.: 1314217-69-0AZD-8529 mesylate (Standard) is the analytical standard of AZD-8529 (mesylate) (HY-107457A). This product is intended for research and analytical applications. AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
-
GRM1 modulator-1
0 ImagesCat. No.: HY-180871CAS No.: 298689-98-2GRM1 modulator-1 is a GRM1 modulator.
