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Cat. No.: HY-131642

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L-γ-Carboxyglutamic acid

(Synonyms: H-Gla-OH)

L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC₅₀ of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders.

For research use only. We do not sell to patients.

CAS No.: 53861-57-7
Formula: C₆H₉NO₆
Molecular Weight:191.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-γ-Carboxyglutamic acid Chemical Structure

CAS No.: 53861-57-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target^[1]

mGluR

102 nM (IC₅₀)

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	102 μM Compound: 30	Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells. Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.	[PMID: 10229625]

In Vitro

L-γ-Carboxyglutamic acid (Compound 30) acts as a competitive antagonist at rat mGluR2-expressing HEK 293 cells with an IC₅₀ of 102 μM, binding via alignment with the extended glutamate conformation and positioning an additional acidic group in the restricted R5 region of the receptor site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 53861-57-7
Molecular Weight 191.14
Formula C₆H₉NO₆
SMILES

OC([C@@H](N)CC(C(O)=O)C(O)=O)=O
Synonyms

H-Gla-OH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jullian N, et al. Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. J Med Chem. 1999;42(9):1546-1555. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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L-γ-Carboxyglutamic acid

All mGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L-γ-Carboxyglutamic acid Related Classifications

HY-131642 Related Classifications