2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. L-γ-Carboxyglutamic acid

L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders.

For research use only. We do not sell to patients.

L-γ-Carboxyglutamic acid

L-γ-Carboxyglutamic acid Chemical Structure

CAS No. : 53861-57-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

L-γ-Carboxyglutamic acid Related Antibodies

Top Publications Citing Use of Products

View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders[1].

IC50 & Target[1]

mGluR

102 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
102 μM
Compound: 30
Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.
Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.
[PMID: 10229625]
In Vitro

L-γ-Carboxyglutamic acid (Compound 30) acts as a competitive antagonist at rat mGluR2-expressing HEK 293 cells with an IC50 of 102 μM, binding via alignment with the extended glutamate conformation and positioning an additional acidic group in the restricted R5 region of the receptor site[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-γ-Carboxyglutamic acid Related Antibodies
Molecular Weight

191.14

Formula

C6H9NO6
CAS No.
SMILES

OC([C@@H](N)CC(C(O)=O)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

L-γ-Carboxyglutamic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-γ-Carboxyglutamic acid53861-57-7H-Gla-OHmGluRMetabotropic glutamate receptorsmGluR2rat mGluR2-expressing HEK 293 cellsglutamateInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
L-γ-Carboxyglutamic acid
Cat. No.:
HY-131642
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.