53861-57-7
Chemical Structure
L-γ-Carboxyglutamic acid
Synonym(s): H-Gla-OH
- CAS No.: 53861-57-7
- Formula:C6H9NO6
- Molecular Weight:191.14
IUPAC Name: (S)-3-aminopropane-1,1,3-tricarboxylic acid
InChIKey: UHBYWPGGCSDKFX-VKHMYHEASA-N
SMILES: OC([C@@H](N)CC(C(O)=O)C(O)=O)=O
Biological Activity: L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders[1].
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L-γ-Carboxyglutamic acid | L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders. | |||||||||||||||||||||
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Keywords
