Macrophage migration inhibitory factor (MIF) Inhibitor

Macrophage migration inhibitory factor (MIF) Inhibitors (27):

Cat. No.	Product Name	Effect	Purity

HY-16692

ISO-1	Inhibitor	99.84%
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC₅₀ of 7 μM.

HY-110063

4-IPP	Inhibitor	99.40%
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).

HY-17009

Iguratimod	Inhibitor	98.49%
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC₅₀ of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC₅₀ of 6.81 μM.

HY-147390

MIF098	Inhibitor	99.99%
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research.

HY-P99262

Imalumab	Inhibitor	98.37%
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer.

HY-181912

D-DT/MIF-1-IN-1	Inhibitor
D-DT/MIF-1-IN-1 (Compound 4h) is a non-competitive, non-covalent inhibitor of MIF-1 and D-DT, with IC₅₀ values of 2.4 μM and 4.0 μM against D-DT, and an IC₅₀ value of 9.8 μM against MIF-1. D-DT/MIF-1-IN-1 inhibits D-DT-induced phosphorylation of ERK and exerts antiproliferative activity in non-small cell lung cancer cells.

HY-182935

PAANIB-1	Inhibitor
PAANIB-1 is a parthanatos associated apoptosis-inducing factor nuclease (PAAN)/macrophage migration inhibitor factor (MIF) inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease.

HY-130332

Mitomycin A	Inhibitor	98.3%
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.

HY-148117

MD13	Inhibitor	99.96%
MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a K_i of 71 nM. MD13 can be used for cancer research.

HY-121356

Carebastine	Inhibitor	99.23%
Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity

HY-110084

BTZO-1	Inhibitor	99.32%
BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a K_d value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.

HY-123814

4-CPPC	Inhibitor	98.20%
4-CPPC is a potent, reversible and selective MIF-2 inhibitor with K_i values of 431, 33 µM for MIF-1, MIF-2, respectively.

HY-W164560

RDR 03785	Inhibitor
RDR 03785 is a covalent MIF inhibitor with an IC₅₀ of 0.36 μM.

HY-149308

MKA031	Inhibitor	98.69%
MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC₅₀ value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection.

HY-115887

R110	Inhibitor	99.90%
R110 is a potent, competitive inhibitor of macrophage migration inhibitory factor 2 (MIF2) tautomerase with an IC₅₀ of 15 μM. R110 has the potential for the research of cancer diseases.

HY-115888

MIF2-IN-1	Inhibitor
MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC₅₀ of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.

HY-144196

MIF-IN-4 hydrochloride	Inhibitor
MIF-IN-4 hydrochloride is potent macrophage migration inhibitory factor (MIF) inhibitor (pIC₅₀=5.01-6). MIF is a cytokine originally found to play a role in inhibiting macrophage migration.

HY-146319

MIF-IN-6	Inhibitor
MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC₅₀ of 1.4 μM and a K_i value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells.

HY-167880

BMY-25551	Inhibitor
BMY-25551 is a Mitomycin A (HY-130332) analogue that is 8 to 20 times more potent than Mitomycin C (HY-13316) in cytotoxicity to murine and human tumor cell lines. BMY-25551 can be utilized in cancer and hematologic depression research.

HY-144190

MIF-IN-1	Inhibitor
MIF-IN-1 (compound 14) is a potent macrophage migration inhibitory factor (MIF) inhibitor (pIC₅₀=6.87).

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