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4-IPP (Synonyms: 4-Iodo-6-phenylpyrimidine)

Cat. No.: HY-110063
Handling Instructions

4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).

For research use only. We do not sell to patients.

4-IPP Chemical Structure

4-IPP Chemical Structure

CAS No. : 41270-96-6

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10 mM * 1 mL in DMSO USD 199 In-stock
Estimated Time of Arrival: December 31
5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF)[1].

IC50 & Target

MIF[1]

In Vitro

4-IPP is a specific suicide substrate for MIF that binds covalently and irreversibly to MIF to inhibit its biologic activity[1].
4-IPP inhibits RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes[1].
4-IPP can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation[1].
4-IPP (0.5-200μM;24-72 hours) inhibits osteoclastogenesis in a dose-dependent manner[1].
4-IPP(5-20μM; 5 days) inhibits RANKL-induced osteoclast differentiation and bone resorption [1].

Cell Cytotoxicity Assay[1]

Cell Line: BMMs
Concentration: 0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM
Incubation Time: 24 hours, 72 hours
Result: Inhibited osteoclastogenesis in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BMMs
Concentration: 5 μM,10 μM, 20 μM
Incubation Time: 1 day, 3 days, 5 days
Result: Inhibited RANKL-induced osteoclast differentiation and bone resorption.
In Vivo

4-IPP (1 mg/kg, 5 mg/kg; every 2 days; for 8 weeks) ameliorates the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation[1].

Animal Model: 8-weeks-old C57BL/6J male mice[1]
Dosage: 1 mg/kg, 5 mg/kg
Administration: Intraperitoneal injection; every 2 days; for 8 weeks
Result: Alleviated OVX-induced osteoporosis.
Molecular Weight

282.08

Formula

C₁₀H₇IN₂

CAS No.

41270-96-6

SMILES

IC1=CC(C2=CC=CC=C2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

4-IPP4-Iodo-6-phenylpyrimidineOthersMIFRANKLosteoclastogenesisosteoblastInhibitorinhibitorinhibit

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4-IPP
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