2. Immunology/Inflammation
  3. Macrophage migration inhibitory factor (MIF)
  4. PAANIB-1

PAANIB-1 is a parthanatos associated apoptosis-inducing factor nuclease (PAAN)/macrophage migration inhibitor factor (MIF) inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease.

For research use only. We do not sell to patients.

PAANIB-1

PAANIB-1 Chemical Structure

CAS No. : 2634726-71-7

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PAANIB-1 Related Antibodies

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Description

PAANIB-1 is a parthanatos associated apoptosis-inducing factor nuclease (PAAN)/macrophage migration inhibitor factor (MIF) inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease[1].

In Vitro

PAANIB-1 (Compound 154) (10 μM; 1 h preincubation) inhibits 38.2% MIF activity and protects SH-SY5Y cells against MNNG (HY-128612)-induced cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAANIB-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: 1 h (pre-incubation); 15 min (MNNG)
Result: Reduced 46.2% MNNG-induced cell death in SH-SY5Y cells.
Molecular Weight

1169.34

Formula

C62H81FN6O15
CAS No.
SMILES

O=C1N2[C@@](C(N(CC/C=C/C(OCC(C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H](C4=CC(F)=CC(OCC(N([C@H](C(N[C@@H](C5=CC=CC=C5)C(N([C@H]1COC(C)(C)C)C)=O)=O)C)C)=O)=C4)CCC6=CC(OC)=C(C=C6)OC)=O)=O)=O)C)=O)C)=O)([H])CCC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAANIB-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAANIB-12634726-71-7PAANIB1PAANIB 1Macrophage migration inhibitory factor (MIF)PAAN/MIF nucleaseParkinson's diseaseMNNGparthanatos-mediated cell deathSH-SY5Y cellsInhibitorinhibitorinhibit

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