MIF2-IN-1
MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- CAS No.: 2917525-79-0
- Formula: C26H19F3N2O2S
- Molecular Weight:480.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 1.0 μM (MIF2)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3 μM
Compound: 5d
|
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
|
[PMID: 35041425] |
| HCC827 | IC50 |
5.2 μM
Compound: 5d
|
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
|
[PMID: 35041425] |
| NCI-H1299 | IC50 |
7.6 μM
Compound: 5d
|
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
|
[PMID: 35041425] |
| NCI-H1650 | IC50 |
5.3 μM
Compound: 5d
|
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
|
[PMID: 35041425] |
Chemical Information
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CAS No. 2917525-79-0
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Molecular Weight 480.50
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Formula C26H19F3N2O2S
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SMILES
O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)