2. Immunology/Inflammation
  3. Macrophage migration inhibitory factor (MIF)
  4. MIF2-IN-1

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.

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MIF2-IN-1

MIF2-IN-1 Chemical Structure

CAS No. : 2917525-79-0

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MIF2-IN-1 Related Antibodies

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Description

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].

IC50 & Target

IC50: 1.0 μM (MIF2)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
3 μM
Compound: 5d
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
HCC827 IC50
5.2 μM
Compound: 5d
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
NCI-H1299 IC50
7.6 μM
Compound: 5d
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
NCI-H1650 IC50
5.3 μM
Compound: 5d
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
Molecular Weight

480.50

Formula

C26H19F3N2O2S
CAS No.
SMILES

O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MIF2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIF2-IN-12917525-79-0Macrophage migration inhibitory factor (MIF)MIF2proliferationcell cycle arrestMAPKcancerInhibitorinhibitorinhibit

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