2917525-79-0
Chemical Structure
MIF2-IN-1
- CAS No.: 2917525-79-0
- Formula:C26H19F3N2O2S
- Molecular Weight:480.50
IUPAC Name: (R)-5-methyl-3-(1-(naphthalen-1-yl)ethyl)-6-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
InChIKey: XKCIYWJZAMFYTL-OAHLLOKOSA-N
SMILES: O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
Biological Activity: MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].
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MIF2-IN-1 | MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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Keywords
