2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Terazosin hydrochloride dihydrate

Terazosin hydrochloride dihydrate 

Cat. No.: HY-B0371A Purity: 99.92%
COA Handling Instructions

Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.

For research use only. We do not sell to patients.

Terazosin hydrochloride dihydrate Chemical Structure

Terazosin hydrochloride dihydrate Chemical Structure

CAS No. : 70024-40-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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100 mg USD 70 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Terazosin hydrochloride dihydrate:

Terazosin hydrochloride dihydrate Related Antibodies

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Description

Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

IC50 & Target

α1-adrenoceptor[1]
In Vitro

Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terazosin hydrochloride dihydrate Related Antibodies
In Vivo

Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

459.92

Appearance

Solid

Formula

C19H30ClN5O6
CAS No.
SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.O.Cl.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (67.95 mM; Need ultrasonic)

H2O : 12.5 mg/mL (27.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1743 mL 10.8715 mL 21.7429 mL
5 mM 0.4349 mL 2.1743 mL 4.3486 mL
10 mM 0.2174 mL 1.0871 mL 2.1743 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 4.55 mg/mL (9.89 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

COA (251 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References
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Terazosin hydrochloride dihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Terazosin hydrochloride dihydrate70024-40-7Adrenergic ReceptorBeta Receptorα1-adrenoceptorbenignprostatichyperplasiahighbloodpressurebladderquinazolineInhibitorinhibitorinhibit

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