1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (R)-Terazosin

(R)-Terazosin 

Cat. No.: HY-B0371B
Handling Instructions

(R)-Terazosin is the R-enantiomer of Terazosin. (R)-Terazosin is a potent α-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively.

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(R)-Terazosin Chemical Structure

(R)-Terazosin Chemical Structure

CAS No. : 109351-34-0

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Description

(R)-Terazosin is the R-enantiomer of Terazosin. (R)-Terazosin is a potent α-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively[1].

IC50 & Target

Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)[1]

In Vitro

(R)-Terazosin is of low affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 3.85 μM, 0.33 μM and 0.37 μM, respectively[1].
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies[1].

In Vivo

(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 7.5 and 5.31, respectively[1].

Molecular Weight

387.43

Formula

C₁₉H₂₅N₅O₄

CAS No.

109351-34-0

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[[email protected]@H]4OCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(R)-TerazosinAdrenergic ReceptorBeta ReceptorLowaffinitysubtypesproveα2-adrenoceptorα1-adrenoceptorInhibitorinhibitorinhibit

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(R)-Terazosin
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