2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Terazosin hydrochloride

Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.

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Terazosin hydrochloride Chemical Structure

Terazosin hydrochloride Chemical Structure

CAS No. : 63074-08-8

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Based on 4 publication(s) in Google Scholar

Other Forms of Terazosin hydrochloride:

Terazosin hydrochloride Related Antibodies

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Description

Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

IC50 & Target

α1-adrenoceptor[1]
In Vitro

Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terazosin hydrochloride Related Antibodies
In Vivo

Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

423.89

Formula

C19H26ClN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (39.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3591 mL 11.7955 mL 23.5910 mL
5 mM 0.4718 mL 2.3591 mL 4.7182 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

COA (250 KB) HNMR (286 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3591 mL 11.7955 mL 23.5910 mL 58.9776 mL
5 mM 0.4718 mL 2.3591 mL 4.7182 mL 11.7955 mL
10 mM 0.2359 mL 1.1796 mL 2.3591 mL 5.8978 mL
15 mM 0.1573 mL 0.7864 mL 1.5727 mL 3.9318 mL
20 mM 0.1180 mL 0.5898 mL 1.1796 mL 2.9489 mL
25 mM 0.0944 mL 0.4718 mL 0.9436 mL 2.3591 mL
30 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9659 mL
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Terazosin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terazosin63074-08-8Adrenergic ReceptorBeta Receptorα1-adrenoceptorbenignprostatichyperplasiahighbloodpressurebladderquinazolineInhibitorinhibitorinhibit

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