1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Nadolol

Nadolol (Synonyms: SQ-11725)

Cat. No.: HY-B0804
Handling Instructions

Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research.

For research use only. We do not sell to patients.

Nadolol Chemical Structure

Nadolol Chemical Structure

CAS No. : 42200-33-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 231 In-stock
Estimated Time of Arrival: December 31
100 mg USD 210 In-stock
Estimated Time of Arrival: December 31
250 mg USD 400 In-stock
Estimated Time of Arrival: December 31
500 mg USD 680 Get quote
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nadolol:

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Description

Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research[1][2][3].

In Vitro

In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM[2].

In Vivo

In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress[3].

Molecular Weight

309.40

Formula

C₁₇H₂₇NO₄

CAS No.

42200-33-9

SMILES

OC1CC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)CC1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

Methanol : 250 mg/mL (808.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2321 mL 16.1603 mL 32.3206 mL
5 mM 0.6464 mL 3.2321 mL 6.4641 mL
10 mM 0.3232 mL 1.6160 mL 3.2321 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NadololSQ-11725SQ11725SQ 11725Adrenergic ReceptorBeta Receptorβ-adrenergicOATP1A2substratehighbloodpressureanginapectorisvascularheadachesInhibitorinhibitorinhibit

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Nadolol
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