Venlafaxine hydrochloride (Synonyms: Wy 45030 hydrochloride)

Name: Venlafaxine hydrochloride
Brand: MedChemExpress
SKU: HY-B0196A
Rating: 5.0 (6 reviews)

Art. -Nr.: HY-B0196A Reinheit: 99.76%: Data Sheet
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Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

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Venlafaxine hydrochloride Chemische Struktur

CAS. Nr. : 99300-78-4

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
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This product is a controlled substance and not for sale in your territory.

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Based on 6 publication(s) in Google Scholar

Other Forms of Venlafaxine hydrochloride:

Venlafaxine-d₆ hydrochloride In-stock
Venlafaxine In-stock
Venlafaxine hydrochloride (Standard) In-stock
(R)-Venlafaxine Angebot einholen
Venlafaxine-d₁₀ hydrochloride Angebot einholen

6 Publications Citing Use of MCE Venlafaxine hydrochloride

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by liquid scintillation counting method	[PMID: 27647372]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine HCl	Inhibition of [3H]-5-HT reuptake in human SERT transfected into HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-HT reuptake in human SERT transfected into HEK293 cells by liquid scintillation counting method	[PMID: 27041397]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine HCl	Inhibition of [3H]-5-HT reuptake in human SERT transfected into HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-HT reuptake in human SERT transfected into HEK293 cells by liquid scintillation counting method	[PMID: 27041397]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting method	[PMID: 27647372]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine HCl	Inhibition of re-uptake of [3H]-5-HT at human SERT expressed in HEK293 cells by liquid scintillation counting Inhibition of re-uptake of [3H]-5-HT at human SERT expressed in HEK293 cells by liquid scintillation counting	[PMID: 28807575]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by microbeta liquid scintillation counting method Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by microbeta liquid scintillation counting method	[PMID: 28274674]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting method	[PMID: 27647372]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method	[PMID: 28274674]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by microbeta liquid scintillation counting method Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by microbeta liquid scintillation counting method	[PMID: 28274674]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine HCl	Inhibition of [3H]-NE reuptake in human NET transfected into HEK293 cells by liquid scintillation counting method Inhibition of [3H]-NE reuptake in human NET transfected into HEK293 cells by liquid scintillation counting method	[PMID: 27041397]
HEK293	IC₅₀	0.204 3 Compound: Venlafaxine HCl	Inhibition of human SERT expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-SERT after 15 mins by liquid scintillation counting Inhibition of human SERT expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-SERT after 15 mins by liquid scintillation counting	[PMID: 26337019]
HEK293	IC₅₀	2.553 3 Compound: Venlafaxine HCl	Inhibition of human NET expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-NET after 15 mins by liquid scintillation counting Inhibition of human NET expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-NET after 15 mins by liquid scintillation counting	[PMID: 26337019]
HEK293	IC₅₀	15700 1 Compound: venlafaxine	Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]
HEK293	IC₅₀	0.204 3 Compound: Venlafaxine HCl	Inhibition of human SERT expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-SERT after 15 mins by liquid scintillation counting Inhibition of human SERT expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-SERT after 15 mins by liquid scintillation counting	[PMID: 26337019]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine HCl	Inhibition of [3H]-NE reuptake in human NET transfected into HEK293 cells by liquid scintillation counting method Inhibition of [3H]-NE reuptake in human NET transfected into HEK293 cells by liquid scintillation counting method	[PMID: 27041397]
HEK293	IC₅₀	0.2 3 Compound: Venlafaxine HCl	Inhibition of re-uptake of [3H]-5-HT at human SERT expressed in HEK293 cells by liquid scintillation counting Inhibition of re-uptake of [3H]-5-HT at human SERT expressed in HEK293 cells by liquid scintillation counting	[PMID: 28807575]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine HCl	Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting	[PMID: 28807575]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine HCl	Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting	[PMID: 28807575]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by liquid scintillation counting method	[PMID: 27647372]
HEK293	IC₅₀	36.1 1 Compound: venlafaxine	Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by liquid scintillation counting method Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by liquid scintillation counting method	[PMID: 27647372]
HEK293	IC₅₀	2.55 3 Compound: Venlafaxine hydrochloride	Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method	[PMID: 28274674]
HEK293	IC₅₀	5720 1 Compound: venlafaxine	Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]
HEK293	IC₅₀	15700 1 Compound: venlafaxine	Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]
HEK293	IC₅₀	2.553 3 Compound: Venlafaxine HCl	Inhibition of human NET expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-NET after 15 mins by liquid scintillation counting Inhibition of human NET expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-NET after 15 mins by liquid scintillation counting	[PMID: 26337019]
HEK293	IC₅₀	36.1 1 Compound: venlafaxine	Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]
HEK293	IC₅₀	5720 1 Compound: venlafaxine	Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay	[PMID: 25221656]

In Vitro

Venlafaxine hydrochloride (Wy 45030 hydrochloride) dose-dependently inhibits binding of the serotonin transporter radioligand [^3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a K_i of 2.48 μM. Venlafaxine hydrochloride inhibits binding of the NE transporter ligand [^3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a K_i of 82 nM^[1].
Venlafaxine hydrochloride inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED₅₀ values of 2 and 54 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Venlafaxine hydrochloride (Wy 45030 hydrochloride; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 180-230 grams^[1]
Dosage:	10, 30, 100 mg/kg
Administration:	IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
Result:	Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED₅₀ values of 12 and 94 mg/kg i.p., respectively.

Molekulargewicht

313.86

Formel

C₁₇H₂₈ClNO₂

CAS. Nr.

99300-78-4

Appearance

Solid

Color

White to off-white

SMILES

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : ≥ 100 mg/mL (318.61 mM)

DMSO : 50 mg/mL (159.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1861 mL	15.9307 mL	31.8613 mL
5 mM	0.6372 mL	3.1861 mL	6.3723 mL
10 mM	0.3186 mL	1.5931 mL	3.1861 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (318.61 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.76%

Select Batch:

Data Sheet (281 KB) SDS (396 KB)

COA (257 KB) HNMR (243 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80. [Content Brief]

[2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.1861 mL	15.9307 mL	31.8613 mL	79.6534 mL
	5 mM	0.6372 mL	3.1861 mL	6.3723 mL	15.9307 mL
	10 mM	0.3186 mL	1.5931 mL	3.1861 mL	7.9653 mL
	15 mM	0.2124 mL	1.0620 mL	2.1241 mL	5.3102 mL
	20 mM	0.1593 mL	0.7965 mL	1.5931 mL	3.9827 mL
	25 mM	0.1274 mL	0.6372 mL	1.2745 mL	3.1861 mL
	30 mM	0.1062 mL	0.5310 mL	1.0620 mL	2.6551 mL
	40 mM	0.0797 mL	0.3983 mL	0.7965 mL	1.9913 mL
	50 mM	0.0637 mL	0.3186 mL	0.6372 mL	1.5931 mL
	60 mM	0.0531 mL	0.2655 mL	0.5310 mL	1.3276 mL
	80 mM	0.0398 mL	0.1991 mL	0.3983 mL	0.9957 mL
	100 mM	0.0319 mL	0.1593 mL	0.3186 mL	0.7965 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Venlafaxine hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Venlafaxine99300-78-4Wy 45030Wy45030Wy-45030Serotonin Transporter5-HTTSERTSLC6A4serotonin5-HTnorepinephrineNEreuptakeantidepressantInhibitorinhibitorinhibit

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Venlafaxine hydrochloride (Synonyms: Wy 45030 hydrochloride)

Kundenbewertung

Other Forms of Venlafaxine hydrochloride:

Venlafaxine hydrochloride Related Antibodies

6 Publications Citing Use of MCE Venlafaxine hydrochloride

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Venlafaxine hydrochloride Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Venlafaxine hydrochloride Related Classifications

Keywords:

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