1. Neuronal Signaling
  2. Serotonin Transporter
  3. Venlafaxine

Venlafaxine (Synonyms: Wy 45030)

Cat. No.: HY-B0196
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Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

For research use only. We do not sell to patients.

Venlafaxine Chemical Structure

Venlafaxine Chemical Structure

CAS No. : 93413-69-5

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Description

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

In Vitro

Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED50 values of 2 and 54 mg/kg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 180-230 grams[1]
Dosage: 10, 30, 100 mg/kg
Administration: IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
Result: Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED50 values of 12 and 94 mg/kg, respectively.
Clinical Trial
Molecular Weight

277.40

Formula

C₁₇H₂₇NO₂

CAS No.

93413-69-5

SMILES

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VenlafaxineWy 45030Wy45030Wy-45030Serotonin Transporter5-HTTSERTSLC6A4serotonin5-HTnorepinephrineNEreuptakeantidepressantInhibitorinhibitorinhibit

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Venlafaxine
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HY-B0196
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