Venlafaxine  (Synonyms: Wy 45030)

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant^[1].

Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [^3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a K_i of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [^3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a K_i of 82 nM^[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED₅₀ values of 2 and 54 mg/kg, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

277.40

C₁₇H₂₇NO₂

93413-69-5

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.  [Content Brief]

  [2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.  [Content Brief]