Cat. No.: HY-B0196

Venlafaxine

(Synonyms: Wy 45030)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

For research use only. We do not sell to patients.

Purity: 99.71%
CAS No.: 93413-69-5
Formula: C₁₇H₂₇NO₂
Molecular Weight:277.40

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Venlafaxine Chemical Structure

CAS No.: 93413-69-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (6)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>10000 nM Compound: 1	Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes	[PMID: 20378347]
CHO	IC₅₀	7340 nM Compound: 3	Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells	[PMID: 20724153]
HEK293	IC₅₀	35 nM Compound: 3	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells	[PMID: 20724153]
HEK293	IC₅₀	>20 nM Compound: 6	Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis	[PMID: 24900709]
HEK293	IC₅₀	680 nM Compound: 6	Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis	[PMID: 24900709]
HEK293	IC₅₀	15767 nM Compound: Venlafaxine	Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	36.1 nM Compound: Venlafaxine	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	5722 nM Compound: Venlafaxine	Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
JAR	IC₅₀	31 nM Compound: 1, venlafaxine	Inhibition of 5HT uptake at human SERT expressed in human JAR cells Inhibition of 5HT uptake at human SERT expressed in human JAR cells	[PMID: 18557608]
JAR	IC₅₀	27 nM Compound: 1	Inhibition of human SERT expressed in human JAR cells Inhibition of human SERT expressed in human JAR cells	[PMID: 20378347]
MDCK	IC₅₀	581 nM Compound: 3	Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells	[PMID: 20724153]

In Vitro

Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [^3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a K_i of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [^3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a K_i of 82 nM^[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED₅₀ values of 2 and 54 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats weighing 180-230 grams^[1]
Dosage:

10, 30, 100 mg/kg
Administration:

IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
Result:

Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED₅₀ values of 12 and 94 mg/kg, respectively.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 93413-69-5
Appearance Solid
Molecular Weight 277.40
Formula C₁₇H₂₇NO₂
Color White to off-white
SMILES

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1
Synonyms

Wy 45030
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (6)

All

Sort by:

Journal Impact Factor

Water Res

Enhanced venlafaxine degradation in amorphous FeS2 under redox-dynamic aqueous environments: Critical role of citrate in electron utilization for boosted hydroxyl radical generation. [Abstract]

2025 Oct 1;288(Pt B):124709. PMID: 41046790
Emerg Contam

2026 Feb 23.
J Med Chem

Exploring Simple Drug Scaffolds from the Generated Database Chemical Space Reveals a Chiral Bicyclic Azepane with Potent Neuropharmacology. [Abstract]

2025 Apr 24. PMID: 40274264
J Agric Food Chem

Fluoride Stimulates Anxiety- and Depression-like Behaviors Associated with SIK2-CRTC1 Signaling Dysfunction. [Abstract]

2021 Nov 17;69(45):13618-13627. PMID: 34735150
Neurosci Bull

Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy. [Abstract]

2025 Jul;41(7):1229-1245. PMID: 40369268
Int Immunopharmacol

Innovative role of the antidepressant imipramine in esophageal squamous cell carcinoma treatment: Promoting apoptosis and protective autophagy. [Abstract]

2025 Jan 6:147:113969. PMID: 39764996

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (720.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6049 mL

18.0245 mL

36.0490 mL

5 mM

0.7210 mL

3.6049 mL

7.2098 mL

10 mM

0.3605 mL

1.8025 mL

3.6049 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80. [Content Brief]

[2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.6049 mL	18.0245 mL	36.0490 mL	90.1226 mL
	5 mM	0.7210 mL	3.6049 mL	7.2098 mL	18.0245 mL
	10 mM	0.3605 mL	1.8025 mL	3.6049 mL	9.0123 mL
	15 mM	0.2403 mL	1.2016 mL	2.4033 mL	6.0082 mL
	20 mM	0.1802 mL	0.9012 mL	1.8025 mL	4.5061 mL
	25 mM	0.1442 mL	0.7210 mL	1.4420 mL	3.6049 mL
	30 mM	0.1202 mL	0.6008 mL	1.2016 mL	3.0041 mL
	40 mM	0.0901 mL	0.4506 mL	0.9012 mL	2.2531 mL
	50 mM	0.0721 mL	0.3605 mL	0.7210 mL	1.8025 mL
	60 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5020 mL
	80 mM	0.0451 mL	0.2253 mL	0.4506 mL	1.1265 mL
	100 mM	0.0360 mL	0.1802 mL	0.3605 mL	0.9012 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Venlafaxine

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Drug Repurposing Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Rare Diseases Drug Library

Antidepressant Compound Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Coagulation and Anti-coagulation Compound Library

Off-patent Drug Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Nephrotoxicity Compound Library

Publications Citing Use of MedChemExpress (MCE) Venlafaxine

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Venlafaxine

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Drug Repurposing Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Rare Diseases Drug Library

Antidepressant Compound Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Coagulation and Anti-coagulation Compound Library

Off-patent Drug Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Nephrotoxicity Compound Library

Publications Citing Use of MedChemExpress (MCE) Venlafaxine

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Venlafaxine Related Classifications

HY-B0196 Related Classifications