Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2809-12. doi: 10.1016/j.bmcl.2010.03.059.
Joseph P Sabatucci  1 ,  Paige E Mahaney ,  Jennifer Leiter ,  Grace Johnston ,  Kevin Burroughs ,  Scott Cosmi ,  Yingru Zhang ,  Douglas Ho ,  Darlene C Deecher ,  Eugene Trybulski
Affiliations
  • 1. Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. [email protected]
PMID: 20378347 DOI: 10.1016/j.bmcl.2010.03.059
Abstract

A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.