Aloesin (Synonyms: Aloeresin)

Name: Aloesin
Brand: MedChemExpress
SKU: HY-N2460
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2460 Purity: 99.81%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.

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Aloesin 화학구조

CAS No. : 30861-27-9

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Aloesin

•University of Paris. 2022 Sep 19.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Aloesin (0-40 μM, 24, 48, and 72 h) inhibits ovarian cancer cell growth in a dose- and time-dependent manner^[1].
Aloesin (0-10 μM; 48 h) arrest the cell cycle at S-phase in a dose-dependent manner in SKOV3 cells^[1].
Aloesin (0-10 μM; 48 h) promotes cell apoptosis in SKOV3 cells^[1].
Aloesin (0-10 μM; 48 h) inhibits the phosphorylation of the MAPK signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MCF10A, T47D, MCF7, MDA-MB-468, and MDA-MB-231 cells
Concentration:	0, 2.5, 5, 10, 20, and 40 μM
Incubation Time:	24, 48, and 72 h
Result:	Exhibited a concentration-dependent and time-dependent killing of diverse ovarian cancer cell lines.

Cell Viability Assay^[1]

Cell Line:	SKOV3 cells
Concentration:	2.5-10 μM
Incubation Time:	48 hours
Result:	Showed a significantly potent toxic effect with an IC₅₀ value of around 5 μM.

Cell Cycle Analysis^[1]

Cell Line:	SKOV3 cells
Concentration:	0, 2.5, 5, and 10 μM
Incubation Time:	48 h
Result:	Decresed the percentage of cells in the G2/M phase gradually with increasing doses, increased the percentages of cells in the S-phase. Downregulated the levels of the S-G2/M-related proteins cyclin A, CDK2, and cyclin D1.

Apoptosis Analysis^[1]

Cell Line:	SKOV3 cells
Concentration:	0, 2.5, 5, and 10 μM
Incubation Time:	48 h
Result:	Detected significant proteolytic cleavage of caspase-3, caspase-9, and PARP1. Increased the expression of Bax and conversely decreased Bcl-2.

Western Blot Analysis^[1]

Cell Line:	SKOV3 cells
Concentration:	0, 2.5, 5, and 10 μM
Incubation Time:	48 h
Result:	Decreased phosphorylated levels of MEK, ERK, MAPK, and JNK.

In Vivo

Aloesin (injection; 20 mg/kg or 40 mg/kg; once daily; 7 w) inhibits tumor growth in a Xenograft model of ovarian cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old athymic nude mice injected with SKOV3 cells
Dosage:	20 mg/kg or 40 mg/kg
Administration:	Injection; 20 mg/kg or 40 mg/kg; once daily; 7 weeks
Result:	Reduced volumes and average weights of dissected tumors significantly compared with the control group.

분자량

394.37

화학식

C₁₉H₂₂O₉

CAS No.

30861-27-9

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C)=C(C(C=C(CC(C)=O)O2)=O)C2=C1[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (253.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5357 mL	12.6784 mL	25.3569 mL
5 mM	0.5071 mL	2.5357 mL	5.0714 mL
10 mM	0.2536 mL	1.2678 mL	2.5357 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.81%

Select Batch:

Data Sheet (284 KB) SDS (394 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang LQ, et al. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Anal Cell Pathol (Amst). 2017;2017:8158254. [Content Brief]

[2]. Wahedi HM, et al. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017 May 15;28:19-26. [Content Brief]

[3]. Y H Jin, et al. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res. 1999 Jun;22(3):232-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5357 mL	12.6784 mL	25.3569 mL	63.3922 mL
	5 mM	0.5071 mL	2.5357 mL	5.0714 mL	12.6784 mL
	10 mM	0.2536 mL	1.2678 mL	2.5357 mL	6.3392 mL
	15 mM	0.1690 mL	0.8452 mL	1.6905 mL	4.2261 mL
	20 mM	0.1268 mL	0.6339 mL	1.2678 mL	3.1696 mL
	25 mM	0.1014 mL	0.5071 mL	1.0143 mL	2.5357 mL
	30 mM	0.0845 mL	0.4226 mL	0.8452 mL	2.1131 mL
	40 mM	0.0634 mL	0.3170 mL	0.6339 mL	1.5848 mL
	50 mM	0.0507 mL	0.2536 mL	0.5071 mL	1.2678 mL
	60 mM	0.0423 mL	0.2113 mL	0.4226 mL	1.0565 mL
	80 mM	0.0317 mL	0.1585 mL	0.3170 mL	0.7924 mL
	100 mM	0.0254 mL	0.1268 mL	0.2536 mL	0.6339 mL

Aloesin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aloesin30861-27-9AloeresinTyrosinaseApoptosisanti-inflammatory activityultraviolet protectionantibacteriuminduce apoptosisovarian cancerMCF10AT47DMCF7MDA-MB-468MDA-MB-231SKOV3Inhibitorinhibitorinhibit

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Aloesin (Synonyms: Aloeresin)

고객리뷰

Aloesin Related Antibodies

1 Publications Citing Use of MCE Aloesin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Aloesin Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Aloesin Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report