2. Anti-infection Neuronal Signaling GPCR/G Protein
  3. Antibiotic Cholecystokinin Receptor
  4. Anthramycin

Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.

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Anthramycin

Anthramycin 構造式

CAS 番号 : 4803-27-4

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Anthramycin 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Cholecystokinin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CCKAR CCKBR

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製品説明

Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice[1][2][3].

体外実験

ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anthramycin 関連抗体
体内実験

Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice[2].
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (20 ± 2 g, 12-14 each group)[2]
Dosage: 0, 0.3, and 0.5 mg/kg
Administration: IP, once, 10 min before the intracisternal (i.c.) injection of CCK
Result: Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
Animal Model: Female CFN Gif rats (140-180 g)[3]
Dosage: 0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
Administration: SC, daily for 8 days
Result: Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
分子量

315.32

分子式

C16H17N3O4
CAS 番号
SMILES

O=C1N2[C@@]([C@H](NC3=C(O)C(C)=CC=C31)O)([H])CC(/C=C/C(N)=O)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Anthramycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anthramycin4803-27-4AntibioticCholecystokinin ReceptorCCK ReceptorPyrolobenzodiazepineantibioticcholecystokininantitumorbenzodiazepineInhibitorinhibitorinhibit

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