2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 

製品番号: HY-P99148 純度: 99.24%
COA Technical Support

Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice.

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容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $120 在庫あり
5 mg $430 在庫あり
10 mg $725 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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製品説明

Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice[1][2][3].

Isotype

Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

TNF alpha
体外実験

Anti-Mouse TNF alpha Antibody (TN3-19.12) (850 ng, 1 h) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 関連抗体
体内実験

Anti-Mouse TNF alpha Antibody (TN3-19.12) (0.3-1 mg, i.p., a single dose) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models[1].

Anti-Mouse TNF alpha Antibody (TN3-19.12) (20 μg/g or 100 μg/injection, i.p., every other day for 21-24 days) prevents diabetes in NOD mice (0-4 weeks)[2].

Anti-Mouse TNF alpha Antibody (TN3-19.12) (50-100 μg, i.p., a single dose) reduces survival of irradiated CD2F1 mice[3].

Anti-Mouse TNF alpha Antibody (TN3-19.12) (200 μg, i.p., 20 h before LPS (HY-D1056)) reduces LPS-induced radioprotection in CD2F1 mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice injected with LNC-8 cells intraperitoneally[1]
Dosage: 0.3 mg
Administration: Intraperitoneal injection
Result: Resulted in a dramatic reduction in the symptoms and severity of EAE (experimental allergic encephalomyelitis).
Alleviated meningeal infiltration.
Animal Model: Mice injected with LNC-8 cells intravenously[1]
Dosage: 1 mg
Administration: Intraperitoneal injection
Result: Reduced the symptoms and severity of EAE.
Reduced the incidence of disease from 89% in the PBS to 20%.
Animal Model: Newborn female NOD mice[2]
Dosage: 20 μg/g
Administration: Intraperitoneally every other day for 24 days
Result: None of mice developed diabetes even after 30 week of age.
Had no significant effect on mouse development and growth, or mortality.
Had no dramatic influence on the development of lymphoid tissues.
Did not potentiate the ability to respond to GAD67, GAD65, CPH, peripherin, and HSP60 at 10 week of age.
Enhanced responses to HEL and OVA.
Inhibited insulitis (only 27% of mice developed a low or moderate degree of insulitis compared to PBS-treated of 100%).
Animal Model: 2-week-old female NOD mice[2]
Dosage: 20 μg/g
Administration: Intraperitoneally every other day for 3 weeks
Result: None of mice developed diabetes even after 34 week of age.
Animal Model: 4-week-old female NOD mice[2]
Dosage: 100 μg/injection
Administration: Intraperitoneally every other day for 3 weeks
Result: Partly prevented disease (about 50%).
Animal Model: Irradiated CD2F1 mice (male, 8-10 week) [3]
Dosage: 100 μg 20 h before irradiation or at 50 μg 1 h after irradiation
Administration: Intraperitoneal injection
Result: Reduced survival of irradiated CD2F1 mice.
Gene ID

21926  [NCBI]

Accession
Application

in vivo TNFα neutralization; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized TNF-alpha/TNFSF2 Protein, Mouse (His, HY-P7417) can bind Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12). The EC50 for this effect is 54.46 ng/mL.
  • Clinical disease scores of mice with active intestinal inflammation and upon Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12, HY-P99148) remission in colitis.
  • Histopathological scores of naive mice, mice with active disease, or Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12, HY-P99148) in colitis.
純度とドキュメンテーション

純度: 99.24%

COA (232 KB) SDS-PAGE (89 KB) SEC-HPLC (164 KB)

Inhibitory Antibodies User Guide (603 KB)
参考文献
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Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFLNC-8EAEDiabetesCD2F1Inhibitorinhibitorinhibit

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製品名:
Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)
製品番号:
HY-P99148
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