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  2. Tnf - tumor necrosis factor Gene

Tnf - tumor necrosis factor Gene

Mus musculus

Also known as DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha

Gene ID: 21926 | Gene type: protein coding

About Tnf

Chromosome 17: 35,418,357-35,420,983 reverse strand.GRCm39:CM001010.3

This gene has 2 transcripts (splice variants), 246 orthologues, 8 paralogues and is associated with 214 phenotypes. Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.) and 16 other tissues.

Summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to Bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Tnf Products(2)

mRNA Protein Name
NM_013693.3 NP_038721.1 tumor necrosis factor isoform 1
NM_001278601.1 NP_001265530.1 tumor necrosis factor isoform 2

Tnf Protein Structure

TNF

TNF: pfam00229 (104 - 234)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor

cachectin

tumor necrosis factor ligand 1f

tumor necrosis factor ligand superfamily member 2

tumor necrosis factor-alpha

Recombinant Tnf Proteins

Cat. No. Product Name Accession Purity
HY-P7090 TNF-alpha/TNFSF2 Protein, Mouse (156a.a) P06804 (L80-L235) ≥95%
HY-P7090A TNF-alpha/TNFSF2 Protein, Mouse (P. pastoris) P06804 (S84-L235) ≥95%
HY-P7417 TNF-alpha/TNFSF2 Protein, Mouse (His) P06804 (L80-L235) ≥95%
HY-P70571 TNF-alpha/TNFSF2 Protein, Mouse (147a.a) P06804 (D89-L235) ≥95%
HY-P7090B TNF-alpha/TNFSF2 Protein, Mouse (156a.a, His) P06804 (L80-L235) ≥95%
HY-P7417AF Animal-Free TNF-alpha/TNFSF2 Protein, Mouse (His) P06804 (L80-L235) ≥95%
HY-P700510 TNF-alpha/TNFSF2 Protein, Mouse (His-SUMO) P06804 (G57-L235) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnf NCBI NCBI:7124
Canis familiaris Tnf NCBI NCBI:403922
Macaca fascicularis Tnf NCBI NCBI:102139631
Susscrofa domestica Tnf NCBI
Leporidae Tnf NCBI
Rattus norvegicus Tnf NCBI NCBI:24835
Macaca mulatta Tnf NCBI NCBI:715467